Pyrimidine compounds continue to attract great interest in the field of organic synthesis due to their various chemical and biological applications observed, especially in recent times. As a result, this review covering some periods from 1957 to 2021 has been prepared to discuss some of the structural pathways of these compounds as well as some of their interactions and applications.

This research aims to analyze the effect of supply chain organizational and supply agility on the performance of supply chain performance through the mediation role of the supply chain strategy in the retail industry. Retail business design creates novelty, it is very important for manufacturers to stay focused on producing goods. The presence of a retail shop will make it easier for consumers to get the goods and services they want. The research sample includes 180 companies or respondents. The results indicate that the supply chain strategy had no significant effect on the supply chain operational performance, while the other hypotheses were stated to be significant, and the supply chain strategy as a mediator had a positive and significant effect on the supply chain operations performance of retail shops. The research includes discovering that supply chain strategy bridges organizational supply chains and supplier agility performance in retail outlets. The research will directly contribute to the growing literature on innovation in supply chain management implementation of retail shops in Indonesia and other countries.

This study aims to explore the power of grit, personality, and creativity to enhance teacher’s professional competence with teaching efficacy mediation. A questionnaire collected the research data through the survey method. This research participant is 386 mathematics, and natural science teachers in Indonesia spread across four provinces (Jakarta, Banten, West Java, Riau) determined by accidental sampling. Data analysis uses path analysis supported by descriptive statistics. The results show that grit, personality, and creativity, had a significant effect on teacher’s professional competence, either directly or indirectly, mediating by teaching efficacy. Personality has a more dominant direct effect on teaching efficacy and professional competence than grit and creativity. Even personality also has an indirect impact on professional competence mediating by teaching efficacy better than grit and creativity. That means the existence of personality more critical than grit and creativity. Therefore, a fit research model about grit, personality, and creativity on teacher’s professional competence mediating by teaching efficacy was found based on data from teachers in Indonesia. This model can be discussed as a reference or discuss by researchers and practitioners in developing professional competence models.

In the classical vehicle routing problem with backhauls (VRPB) the customers are divided into two sets; the linehaul and backhaul customers, so that the distribution and collection services of goods are separated into different routes. This is justified by the need to avoid the reorganization of the loads inside the vehicles, to reduce the return of the vehicles with empty load and to give greater priority to the customers of the linehaul. Many logistics companies have special responsibility to make their operations greener, and electric vehicles (EVs) can be an efficient solution. Thus, when the fleet consists of electric vehicles (EVs), the driving range is limited due to their battery capacities and, therefore, it is necessary to visit recharging stations along their route. In this paper the electric vehicle routing problem with backhauls (EVRPB) is introduced and formulated as a mixed integer linear programming model. This formulation is based on the generalization of the open vehicle routing problem considering a set of new constraints focussed on maintaining the arborescence condition of the linehaul and backhaul paths. Different charging points for the EVs are considered in order to recharge the battery at the end of the linehaul route or during the course of the backhaul route. Finally, a heuristic initialization methodology is proposed, in which an auxiliary graph is used for the efficient coding of feasible solutions to the problem. The operation and effectiveness of the proposed formulation is tested on two VRPB instance datasets of literature which have been adapted to the EVRPB.

A new series of 2-[3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-4-pyrazolyl]-3-aryl-1,3-thiazolan-4-one 5(a-i) have been designed, synthesized and evaluated for their in vitro antibacterial activity against Gram positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p), Micrococcus luteus (IFC 12708) and Gram negative bacteria viz. Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028), Escherichia coli (ATCC 25922) the antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185), Trichophyton mentagrophytes (IFO 40996). Antibacterial evaluation indicates that compounds containing 4-methoxyphenyl 5c, 4-fluorophenyl 5d and 2,5-difluorophenyl 5h groups on thiazolidinone ring showed significant activity equal to that of standard drug. The antifungal evaluation shows that compound 5c is highly active against A. fumigatus, compound 5d and 5h were also active against C. albicans and A. fumigatus.

Passion has known widely as a factor that influences motivation positively. However, its operationalization in decision-making remains unclear. To fill this gap, the author develops the concept and model of the passionate decision through which one can predict future inclination to a choice. Using university choice as a research context, the data from 350 respondents reveals that the model is robust and has good nomological validity. As expected, the passionate decision can explain 98% of future loyalty. The construct is also able to represent 93% of positive affect, decision confidence, and self-efficacy, usually used as the indicators of decision quality. Decision justifiability and mastery goals contribute positively to the passionate decision, whereas performance-avoidance goals show the adverse contribution, and performance-approach goals show no contribution. This re-search still uses harmonious passion. Further research can use obsessive passion to investigate whether both have the same or different capability in explaining future choice engagement.

The effect of information security on the e-supply chain attracted attention to investigate its relationship with the mediating role of supply chain risk in the logistics and distribution industry in the United Arab Emirates (UAE). The proposed research explored the mediating effect of supply chain risk in the logistics and distribution industry, providing unique insights for future research, literature, and targeted sectors. A descriptive, causal and analytical design with quantitative research technique was applied to the proposed research model. A sample of 301 respondents from the managerial departments of 176 logistics and distribution companies in Dubai and Abu Dhabi was used to assess the research variables. The findings revealed that the impact of information systems was positively associated with the e-supply chain, while the indirect impact of supply chain risk significantly positively impacted the e-supply chain. The research is limited to assessing the supply chain risk as an intermediary. For future research, exploring the SC risk prevention strategies' impact on the E-supply chain is recommended. Research findings are anticipated to assist communities of practice in making better information security decisions in the context of e-supply chain by clearly implementing information security policies internally and externally to enhance e-supply chain performance and SC risk management.

Effective supply chain management (SCM) has become a potentially valuable way to secure competitive advantage and improve organizational performance because competition is no longer between organizations but between supply chains. This study examines the relationship between the influence of SCM practices on competitive advantage and organizational performance. The data for this study were collected from 165 employees in one of the SMEs in the Halal Agroindustry in Indonesia. Survey data were analyzed using partial least squares structural equation modeling (PLS-SEM). The results suggest that higher levels of SCM practices can lead to increased competitive advantage and improved organizational performance. Also, competitive advantage can have a direct positive impact on organizational performance. This study also confirms the mediating effect of competitive advantage on the relationship between SCM practices and organizational performance.

The purpose of this paper is to present the relief operations (RO), responding to a sudden, natural, national disaster (SNND) as a multi-mode resource-constrain multi-project scheduling problem (MRCMPSP). A conceptual framework at a strategic level is constructed and the Colombian RO for an earthquake response is shown as an illustrative case. We concluded that RO can be addressed as a MRCMPSP and that for Colombian case, it is a convenient way to board it. Addressing RO as a MRCMPSP allows managers to implement different project scheduling tools successful in other contexts.

This paper evaluates factors influencing the player loyalty with golf courses. The main factors include service quality, perceived value, customer (player) satisfaction, and golf course image. The results indicate that in the golf course business in the Northern Vietnam, factors such as perceived value and customer satisfaction had significant impacts on player’s loyalty. Service quality did not have any direct impact on player’s loyalty but highly influenced player loyalty through other mediators. Golf course image that had not been studied in the golf tourism business before, was also proved its significant role on impacting the golfer loyalty.