The validation of bioanalytical methods holds critical importance for regulatory agencies and organizations dedicated to ensuring the safety, efficacy, and quality of pharmaceuticals. In this context, the recent release of the ICH M10 guideline in May 2022 represents a significant milestone in standardizing bioanalytical method validation globally. However, this guideline lacks explicit experimental protocols for implementation. In this study, we address the practical implementation of the newly released ICH M10 guideline by providing a detailed validation protocol for a bioanalytical method. Our method specifically targets tiaprofenic acid, a widely used nonsteroidal anti-inflammatory drug. Tiaprofenic acid is a critical component in bioequivalence studies, underscoring the necessity for precise and accurate quantification within complex biological matrices. The integration of the accuracy profile approach, a statistical tool, enhances the significance of this work. This approach aids in assessing the accuracy and precision of bioanalytical methods, establishing confidence intervals around measured concentrations, and quantifying the level of accuracy and precision expected when using the validated method.

This study investigates the impact of introducing financial technology (Fintech) on increasing the financial viability of small and medium enterprises (SMEs) operating in the IT sector in the United Arab Emirates (UAE). By identifying the obstacles that SMEs experience while dealing digital transformation, this study aims to show how the emerging financial technologies, including digital banking, peer-to-peer lending, and AI applications, can drive enhancements in financial utilization and the innovation of banking products, cost-cuts, increased organizational productivity, and better client experiences. A quantitative research approach was implemented, and the research tool used was a structured questionnaire developed to capture respondents’ data from 250 respondents from SMEs in the UAE. Descriptive and inferential statistics of correlation and regression analysis were done using the stratified random sampling technique. Results indicated that fintech adoption enhances financial performance in SMEs. Specifically, increased accessibility shows a strong positive correlation with financial performance (r = 0.998, p < 0.01), while enhanced efficiency and improved customer experience also show strong correlations (r = 0.635, p < 0.01). The variable "Increased Accessibility" showed the most significant effect on the financial performance of SMEs, with a highly significant positive correlation and the strongest predictive value in the regression analysis. This study concludes that the implementation of fintech solutions offers significant opportunities for improving the financial performance of SMEs and recommends increased investment in fintech and appropriate regulation for that purpose.

The global rise of life-threatening diseases, particularly breast cancer, has emerged as a grave public health challenge. Recognizing the distinct structural demands of anti-breast cancer targets, we have synthesized Thiophene-DHPMs analogs by scaffold hopping approach to exhibit versatility having the ability to target proteins targets of cancer and their interactions contingent upon the various substitutions on them. We have harnessed MCRto synthesize novel Thiophene-DHPMs (4a-4d) derivatives introducing an efficient Biginelli protocol approach. All derivatives are characterized through techniques including FTIR and ¹H NMR and evaluated by in vitro SRB assay method on MCF-7 cell line, compared against positive control ADR. Molecular docking studies against kinesin spindle protein Eg5 (1Q0B) revealed superior binding interactions and docking scores (> 8 Kcal) compared to the prototype Eg5 inhibitor Monastrol. Compound 4a binds via Hydrogen bond interaction to target Eg5 with ALA-133, PRO-137, TYR-211 In vitro evaluation of results indicates that compound 4a found to be moderately active (GI₅₀ = -4.41) compared to positive control ADR (GI₅₀ = -7.76) against MCF-7 cells. Compound 4a demonstrates significant activity due to the presence of R=C2H5, X= S, and thiophene ring.

In this digital era, collaborative management is needed to improve service quality and be supported by multiple stakeholder participation to provide optimal service. This research aims to investigate the role of collaborative governance in the quality of immigration services and the role of numerous stakeholder participation in the quality of immigration services. Investigate the correlation between supply chain service and service quality. This research method uses a quantitative method approach, research data was obtained by distributing online questionnaires via the Google Form platform. The questionnaire is designed to contain statement items on a Likert scale of 1 to 7. A 7-point Likert scale can minimize measurement errors and be more precise. The Likert scale used in this research is (1) strongly disagree, (2) disagree, (3) quite disagree, (4) Neutral, (5) quite agree, (6) agree, (7) Strongly agree. The respondents for this research were 567 senior employees of the immigration department in Indonesia who were determined using a simple random sampling method. Research data analysis uses the partial least squares (PLS) structural equation modelling (SEM) approach with data processing tools using SmartPLS 4.0 software. The variables in this research are the dependent variables, namely collaborative governance, and multiple stakeholder participation and the dependent variable is the quality of immigration services. The stages of data analysis are validity testing, reliability testing and significance testing of hypothesis testing. Based on the results of the analysis and discussion that have been presented in this research, this research uses the Partial Least Square (PLS) method for data analysis, it can be concluded as follows, it is concluded that collaborative governance has a positive and significant relationship to the quality of immigration services, multiple stakeholder participation has a positive and significant relationship to the quality of immigration services. Supply chain service has a positive and significant relationship with service quality. Implementing collaborative governance can encourage improvements in the quality of immigration services. Implementing multiple stakeholder participation can encourage improvements in the quality of immigration services.

In current paper, a novel, green, efficient and recyclable magnetic nanocatalyst (α-Fe₂O₃@MoS₂@Ni) was prepared and characterized by spectroscopic and microscopic techniques (FT-IR, XRD, SEM, EDX, TEM and VSM). α-Fe₂O₃@MoS₂@Ni magnetic nanoparticles (MNPs) were utilized for preparation of 1,2,4-triazolidine-3-thiones and spiro-triazole hybrid series. In this method, a series of triazole derivatives prepared from the reaction between thiosemicarbazide or semicarbazide with diverse isatine derivatives or various arylaldehydes and ketones at room temperature in water as solvent with great yields and short reaction times. α-Fe₂O₃@MoS₂@Ni MNPs was simply removed from the reaction mixture and was reused for five times without any notable changes in its catalytic activity.

As one of the busiest airports in the world, organizational performance is the main focus. Problems that occur in organizations are many employees who complain about their work, employees who cannot fully comply with applicable regulations and policies, many employees who often come late to the office and do not comply with working hours according to the work times determined by the company. This research aims to analyze and test the influence of Quality of Work Life (QWL) and Knowledge Management on Organizational Citizenship Behavior which is mediated by Job Satisfaction, moderated by Knowledge Sharing and Self Efficacy at Angkasa Pura. The population in this research was Angkasa Pura Indonesia employees, totaling 151 people. The sample used was 110 employees which was calculated based on the Slovin formula. The sampling method uses convenience sampling. The data collection method uses a survey method, with the research instrument being a questionnaire. This research method uses the Partial Least Square (PLS) data analysis method using SmartPLS 3.0 software. The research results show that the quality of work life has no effect on organizational citizenship behavior. Knowledge management has a positive and significant effect on organizational citizenship behavior. Quality of work life and Knowledge management has a positive and significant effect on job satisfaction. Job satisfaction has a positive and significant effect on organizational citizenship behavior. Job satisfaction is unable to mediate the influence of quality of work life on organizational citizenship behavior. Job satisfaction is able to partially mediate the influence of knowledge management on organizational citizenship behavior.

Triazolo[3,4-b]thiadiazoles are a class of heterocyclic compounds, which have attracted great interest in medicinal chemistry owing to their wide range of pharmacological activities. A number of triazoles fused to thiadiazoles are incorporated into a wide variety of therapeutically important compounds possessing a broad spectrum of biological activities. Considering such a significant pharmacological potential, as well as wide synthetic possibilities triazolo-thiadiazoles have received considerable attention from scientific community and are extensively used for construction of prospective drug-likes molecules. In this review, we summarized the literature data about the main synthetic approaches for obtaining condensed heterocyclic compounds based on triazolo[3,4-b][1,3,4]thiadiazole scaffold as promising objects for modern bioorganic and medicinal chemistry.

This paper examined technology information as the factor that drives productivity among Small and Medium Enterprises (SMEs), particularly the effect of innovation on the performance of SMEs and the effect of Customer Relationship Management (CRM) Technology on industrial performance. The mediation of CRM Technology on the effect of innovation on company performance was examined as well. Survey questionnaire was distributed online to 544 firms, and data were analyzed through structural equation models using Amos version 23. Results show that innovation increases productivity (performance) of small businesses and plays a positive role on information systems. However, innovation had an insignificant role on industrial Performance. Meanwhile, CRM Technology shows no mediation in the relationship between innovation and performance. Generally, results proved the significance of innovation in enhancing company performance.

The objective of this research was to gain a deeper comprehension of how individuals perceive and respond to cybersecurity and how various internal and external factors influence these behaviors and attitudes. Conducted at ABC organization in Saudi Arabia, the study employed the qualitative methodology. Two online focus groups were employed featuring open-ended questions. The data were subsequently analyzed thematically using inductive and deductive coding techniques. Several theories were used as theoretical lenses to analyze the data. After the collected data had been analyzed, three main themes emerged: (a) perceived safeguards and threats, (b) personal and professional experience in information security, and (c) necessity of education and raising awareness. Additionally, two sub-themes were revealed: (a) costs and benefits and (b) necessity of safeguard measures and attaining trust. The study’s identified themes and sub-themes offer a thorough comprehension of the demographic, social, cultural, and internalized factors influencing cybersecurity-related behavior. The identified themes could potentially be applicable to other settings. Future qualitative research could further explore the transferability of these findings by conducting similar studies in different organizational, cultural, and linguistic contexts. It is also recommended for future quantitative research to delve deeper than surface-level data and consider underlying meaning, factors, connections, or relationships that may skew the results. It is crucial to delve into hidden meanings, not just accept data at face value.

Herein, modern green synthesis approaches are studied to assemble N-heterylarenes scaffolds via a non-catalyzed intramolecular 5/6-exo-dig cyclocondensation reaction based on the in-situ generation of arenehydrazonopentan-/hexan-2-one. Accordingly, the formation of two N-heteryl moieties, pyrazol-1-yl and pyridazin-1(4H)-yl, was initially studied. Therefore, appropriate fluorophenyl was first converted into their respective phenylhydrazine by SNAr reaction and then reacted with different trigonal carbonyl bielectrophiles (-CO-, -CO₂R, and -CO₂H) in ethanol in the presence of US, MW, IR, and an IR· US irradiation mixture. Cyclic nitrogenous cores were best obtained when subjected to microwave irradiation with ketone and arylhydrazine as starting reagents, allowing them to get excellent yields quickly. Arylhydrazine reactants featuring Π-donor groups underwent the best 5/6-exo-dig type annulment reaction. Presumably, the observed improvements in EDG-dependent reaction efficiency reflect changes in the nucleophilicity of arylhydrazines intermediates as α-nucleophilic reactants.