An ecofriendly methods for the synthesis of medicinally important class of heterocyclic scaffold, pyrazole 4-carbonitrile derivatives by one pot three component reaction of malononitrile, phenyl hydrazine and aromatic aldehyde has been achieved at room temperature. Greener protocols of reaction are followed by using sodium chloride to accelerate the reaction in aqueous media. Present methodology is a condition based divergence on synthesis of pyrazole by using simple salts, which offers several advantages like use of aqueous media and high yield of product along with short reaction time, simple work up procedure, no waste or by products, avoid the use of heavy metals or nanoparticles are the fascinating characteristics of reaction.

The reaction of lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole with in position 5 of the thiazole ring and double lithiation with t-butyllithium (t-BuLi) in positions 2 and 5 lithium diisopropylamide (LDA) are investigated. When lithiated and dilithiated thiazoles were treated with different electrophiles, a number of trifunctional 1,3-thiazoles were obtained with high yields.

The total synthesis of mycophenolic acid (MPA), a potent immunosuppressant, was modified. The obtained mycophenolic acid was suitable for further preparation of new prospective immunosuppressants with improved therapeutic properties.

A new method of amidation of Carboxy Multi Walled Carbon Nanotubes (MWCNT-COOH) with diamine monomer such as ethylene diamine (EDA) and O-Phenylenediamine (OPDA) was applied by using a solution blending technique. The structure and properties of these composites have been investigated by FTIR, SEM, TEM, XRD, UV, DSC and TGA. The formation of Poly [MWCNT/ Amide] composites was confirmed and the DC electrical conductivity of poly-composites was in the range 4.5×10^-6-5.3×10^-6 S/cm due to the interaction between the nanotubes.

A molecular mechanism of the [3+2] cycloaddition has been explored using various DFT theoretical levels. It was found that the reaction proceeds via transition states with different synchronicity, but no intervention of the theoretical possible zwitterionic intermediates. Additionally, regioselectivity of the cycloaddition process has been analysed using vibrational analysis of localised TSs