Indole is a hazardous substance existing in the curl oil, which released to the environment by various industrial activities; thus, decreasing its ratio from nature seems to be essential. In this study, a facial pathway for loading Cu(II) particles on MCM-41 mesoporous material was introduced as an efficient catalyst for indole oxidation. The obtained catalyst was characterized by XRD, FESEM, EDS, TEM and BET/BJH techniques. Based on Taguchi method, indole oxidation via prepared catalyst at mild condition was evaluated. By applying this method, the operating factors including Indole initial concentration (mg/L), pH value and the mass of catalyst (g) were optimized. It was found that pH plays the most crucial role in indole oxidation, on the other word, in alkaline environment; indole oxidation was happened with higher yield.

The regioselectivity of the [3+2] cycloaddition reactions between benzonitrile N-oxide as three-atom component and two series of para-substituted β-nitrostyrene analogues was analysed in the framework of
a Molecular Electron Density Theory. All of the considered processes were found to be initiated by the attack of the most nucleophilic oxygen atom in the benzonitrile N-oxide on the most electrophilic carbon atom (C_α) in the nitroalkenes. This type of interaction favours the formation of 4-nitro-substituted
Δ²-isoxazolines.

New series of mononuclear octahedral Ru(III) complexes of general formula [RuL^1-3Cl]Cl₂ (1-3) where L = dianion of Schiff bases namely: 2,2'-(((1E,1'E)-thiophene-2,5-diylbis(methaneylylidene))bis(azaneylylidene))diphenol (H₂L¹), 2,2'-(((1E,1'E)-thiophene-2,5-diylbis(methaneylylidene))bis(azaneylylidene))dibenzenethiol (H2L2) and 2,2'-(((1E,1'E)-thiophene-2,5-diylbis(methaneylyli-dene))bis(azaneylyli-dene))-dibenzoic acid (H₂L³), respectively are synthesized and characterized by different physico-chemical techniques. The results of interaction of complexes with CT-DNA supported that, the Ru (III) complexes bind to DNA via an intercalative mode. The interaction has also been investigated by gel electrophoresis. Interestingly, it was found that all Ru(III) complexes cleave super coiled (SC) pUC19 plasmid DNA efficiently in the absence of an external agent. Further, the antiproliferative activity of the complexes on Human Cervical Cancer Cells (HeLa) and Human Breast Cancer Cells (MCF-7) were evaluated by MTT assay, which revealed that, all the complexes showed more intense inhibition against HeLa and MCF-7 cell lines, particularly Ru(III) complex (3) attenuated the strongest proliferation, allowing its use as chemotherapeutic agent for cancer treatment.

A new series of 4-amino-4H-1,2,4-triazole derivatives, 3a-f and 5a-f were synthesized by using various aryl aldehydes and ketones. FT-IR, ¹H NMR, ¹³C NMR and mass spectral studies were characteristic of the synthesized compounds. These new compounds were screened in male wistar rats and compared with the standard drug for their anticonvulsant activity against maximal electroshock seizure (MES) model. Compounds 3b and 5d of this sequence were found to be the most active. The same compound did not demonstrate neurotoxicity at the administered maximum dose (100 mg / kg) and these compounds showed good protection compared to other compounds.

A synthesis of 2-amino-4-(R)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives (4a-l) in single flasks containing aromatic aldehydes (1a-l), malononitrile (2), and dimedone (3) by using green catalyst, extract of orange without solvent under ultrasound irradiations and reflux condition. Synthesis of 2-amino-4-(R)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives (4a-l) show potent in-vitro anti-inflammatory activity. All synthesized compounds were characterized by FTIR, ¹H NMR, ¹³C NMR and mass spectroscopic data & elemental analysis.