Here derivatives of imidazo[2,1-b][1,3]thiazines are attractive objects for organic and medicinal chemists. In the present work chemoselective conditions for oxidation of the sulfur atom in the 6-(2-pyridinyloxy)substituted (benzo)imidazo[2,1-b][1,3]thiazines to the corresponding sulfoxides were proposed and their synthesis was performed. Synthesized sulfoxides exist in the diastereomeric mixture and individual diastereomers 2a-e and 3a-e were obtained using a chromatographic technique. The structure of compounds 2a-e and 3a-e were characterized using ¹H, ¹³C NMR, LC-MS spectra, and X-ray analysis for derivative 2b. The anti-inflammatory activity screening in vivo was performed using the carrageenan model of inflammatory paw edema in white rats for all the diastereomeric mixtures and individual diastereomers. Diastereomer 2c possessed an anti-inflammatory effect with an inflammation inhibition index of 46.1% which was equal to the activity of the reference drug diclofenac sodium.

The chemistry of Schiff base has received remarkable attention in different applications, both organic synthesis and industries. Over the past few years many reports have been on the synthesis, characterization and application of vanadium Schiff base complexes. However, heterogeneous vanadium Schiff base catalysts are active for various oxidation reactions, making catalytic oxidation of hydrocarbons a great interest. This review summarizes the recent development of organic substrate oxidation with heterogeneous vanadium Schiff base catalysts.

In the present work the synthesis of 4-phenyl-2, 6-di (thiazol-2-yl) pyridine copper chloride (abbreviated as Cu-DTPy) complex using copper (II) chloride and 2, 6-di (thiazol-2-yl) pyridine has been carried out. The complex has been specified by UV-Vis, FT-IR, CHNS and ESI-MS methods of analysis. The synthesized copper complex has been used as catalyst in the oxidation of p-aminophenol using hexacyanoferrate (III) ions as an oxidant in aqueous alkaline medium by kinetic-spectrophotometric method. This experimental work was carried out at optimum pH 11.0 and temperature 25ºC. The variation of effect of concentration of p-aminophenol (abbreviated as PAP), hexacyanoferrate (III) ions, and Cu-DTPy catalyst on reaction rate has been studied. Thermodynamic parameters such as free energy of activation, activation energy, enthalpy and frequency factor have been evaluated with the change in rate of the reaction at four disparate temperatures i.e. 25-40ᵒC. The oxidation products have been identified by FT-IR and ESI-MS spectroscopic analytical techniques. The major product of this reaction is NN’-bis-(p-hydroxyphenyl)-2-hydroxy-5-amino-1,4-benzoquinone di-imine. Thus, this method is highly efficient and environmentally safe to remove PAP from polluted water resources.

A new method for the direct oxidation of aromatic amines to azobenzenes employing aqueous tertiary-butyl hydrogen peroxide and potassium tertiary butoxide as an oxidant and base, respectively is described. The desired products are obtained in good yields. The developed protocol is associated with certain advantages for example free from any metal oxidants.

Kinetic study of oxidation of toluidine blue (TB+) by periodate was carried out in aqueous medium and also in the cetyl trimethyl ammonium bromide (CTAB) reverse micellar medium. In both the media reaction obeys first order kinetics with respect to each of the reactants. In the reverse micellar medium, the reaction is forty times faster compared to aqueous medium under identical experimental conditions. The pronounced acceleration is accounted for by the lower micro polarity and the concentration effect present in the bound water of reverse micelles. In CTAB reverse micellar medium, the pseudo first order rate constant (k’) of the reaction is almost constant at all values of W, {W=[H2O]/[CTAB]} indicating that the reaction takes place on the micellar surface and results were explained by modified Berezin pseudo phase model..

The total synthesis of mycophenolic acid (MPA), a potent immunosuppressant, was modified. The obtained mycophenolic acid was suitable for further preparation of new prospective immunosuppressants with improved therapeutic properties.

Oxidation of alcohols to carbonyl compounds has become an important issue in the process industry as well as many other applications. In this method, various benzylic alcohols were successfully converted to corresponding aldehydes and ketones under transition metal-free condition using hydrogen peroxide in the presence of some amount of catalytic acidic silica gel. Silica gel is inexpensive and available. One of the most important features of this method is its short reaction time.

A mild and efficient procedure has been proposed for oxidation of benzylic alcohols to the corresponding carbonyl compounds using polymer-supported dichloroiodate (PSDI). The oxidations were carried out in acetonitrile solution, affording the corresponding aldehydes or ketones in high substrate conversion and short reaction time under mild aprotic conditions. Excellent selectivity was observed between primary benzyl alcohols and secondary ones as well as non-benzylic alcohols in the oxidation reactions. The catalyst can be easily prepared and regenerated.

Tetraphenylporphyrin (TPP) and copper tetraphenylporphyrin (CuTPP) were synthesized and characterized by IR, UV-Vis, 1HNMR and 13CNMR. The CuTPP nanoparticles were synthesized by sonication and mixed solvent methods. These nanoparticles were characterized by AFM and SEM images and UV-Vis spectra. The catalytic activity of nanoparticles was investigated by oxidation of o-choloro and o-hydroxy benzyl alcohols in presence of molecular oxygen and isobutyraldehyde. The yields of oxidation of o-hydroxy benzyl alcohol by the two catalysts, CuTPP NPs and CuTPP, are 96.5% and ~ 2%, respectively. It is very obvious that the oxidation at the presence of CuTPP NPs catalyst is very high but selectivity for both reactants is 100%.?