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Growing Science » Current Chemistry Letters » Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 8 Issue 4 pp. 199-210 , 2019

Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides Pages 199-210 Right click to download the paper Download PDF

Authors: Oleh V. Shablykin, Yurii Eu. Kornii, Victoriya V. Dyakonenko, Olga V. Shablykina, Volodymyr S. Brovarets

📋 Author Affiliations:
doi 10.5267/j.ccl.2019.5.003
Crossmark

🔑 Keywords: (Z)-N-(5-(Dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulphonamides, Heterocyclization, Anticancer Activity

Abstract: Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides. According to the National Cancer Institute (USA) examinations, two of the six synthesized sulfonamides showed a high anticancer activity.

How to cite this paper
APA: Shablykin, O., Kornii, Y., Dyakonenko, V., Shablykina, O & Brovarets, V. (2019). Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides. Current Chemistry Letters, 8(4), 199-210.
Chicago/Turabian: Shablykin, O., Kornii, Y., Dyakonenko, V., Shablykina, O & Brovarets, V. 2019. "Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides." Current Chemistry Letters 8, no. 4 (2019): 199-210.
AMA: Shablykin, O., Kornii, Y., Dyakonenko, V., Shablykina, O & Brovarets, V. Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides. Current Chemistry Letters. 2019;8(4):199-210.

References

1 Tréfouël J., Tréfouël T., Nitti F., & Bovet D. (1935) Activité du p-aminophénylsulfamide sur l'infection streptococcique expérimentale de la souris et du lapin. C. R. Soc. Biol., 120, 756-758.
2 Kachaeva M. V., Pilyo S. G., Demydchuk B. A., Prokopenko V. M., Zhirnov, V. V., & Brovarets, V. S. (2018) 4-Cyano-1,3-oxazole-5-sulfonamides as Novel Promising Anticancer Lead Compounds. Intern. J. Current Res., 10(5) 69410-69425.
3 Kachaeva M. V., Hodyna D. M., Semenyuta I. V., Pilyo S. G., Prokopenko V. M., Kovalishyn V. V., Metelytsia L. O., & Brovarets V. S. (2018) Design, synthesis and evaluation of novel sulfonamides as potential anticancer agents. Comput. Biol. Chem., 74, 294-303.
4 Zyabrev V. S., Babiy S. B, Turov K. V., Vasilenko O. M., Vinogradova T. K., & Brovarets, V. S. (2015) 2,4-Disulfonyl-5-cycloamino substituted thiazoles and their using as anticancer drugs.
Patent 109165 UA (in Ukrainian).
5 Aspatwar A., Becker H. M., Parvathaneni N. K., Hammaren M., Svorjova A. Barker H., Supuran C. T., Dubois L., Lambin P., Parikka M., Parkkila S., & Winum J. Y. (2018) Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. J. Enzyme Inhib. Med. Chem., 33(1) 1064-1073.
6 Matsumura K., Saraie T., & Hashimoto N. (1976) Studies of Nitriles. VII. Synthesis and Properties of 2-Amino-3,3-dichloroacrylonitrile (ADAN). Chem. Pharm. Bull., 24(5) 912-923.
7 Matsumura K., Saraie T., & Hashimoto N. (1976) Studies of Nitriles. VIII. Reaction of N-Acyl Derivatives of 2-Amino-3,3-dichloroacrylonitrile (ADAN) with Amines. (1). A New Synthesis of
2-Substituted-5-(substituted amino)-oxazole-4-carbonitriles and -4-N-acylcarbocamides. Chem. Pharm. Bull., 24(5) 924-940.
8 Matsumura K., Saraie T., & Hashimoto N. (1976) Studies of Nitriles. XI. Preparation and chemistry of Schiff Bases of ADAN, 2-Amino-3,3-dichloroacrylonitrile. A highly Effective Conversion into 2-Substituted-4(5)-chloro-imidazole-5(4)-carbaldehydes. Chem. Pharm. Bull., 24 (5) 960-969.
9 Kimura H., Yukitake H., Tajima Y., Suzuki H., Chikatsu T., Morimoto S., Funabashi Y., Omae H., Ito T., Yoneda Y., & Takizawa M. (2010) ITZ-1, a Client-Selective Hsp90 Inhibitor, Efficiently Induces Heat Shock Factor 1 Activation. Chem. Biol., 17 (1) 18-27.
10 Sheldrick G. (2008) A short history of SHELX. Acta Cryst., Sect. A., 64 (Pt 1) 112-122.
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Journal: Current Chemistry Letters | Year: 2019 | Volume: 8 | Issue: 4 | Views: 1952 | Reviews: 0

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