Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides. According to the National Cancer Institute (USA) examinations, two of the six synthesized sulfonamides showed a high anticancer activity.
Growing Science » Authors » Victoriya V. Dyakonenko
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Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides Pages 199-210
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Authors: Oleh V. Shablykin, Yurii Eu. Kornii, Victoriya V. Dyakonenko, Olga V. Shablykina, Volodymyr S. Brovarets
Keywords: (Z)-N-(5-(Dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulphonamides, Heterocyclization, Anticancer Activity
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Journal: CCL | Year: 2019 | Volume: 8 | Issue: 4 | Views: 1824 | Reviews: 0