The research aims to investigate how strategic entrepreneurship through innovative effectiveness is used to create value within firms. Using structural equation modeling, data from 55 private hospitals in Jordan were gathered. For this research, 230 directors, managers, and department heads were enlisted. An entrepreneurial mindset was found to have a significant and positive correlation with innovative effectiveness while having a business alignment also had a positive and significant correlation with innovative effectiveness. However, innovative effectiveness had a positive but insignificant correlation with the creation of firm value. The research concluded that strategic entrepreneurship had a positive effect on the creation of firm value.

The inhibiting effect of chloroquine compounds (ChCs) on the SARS-CoV-2 virus represents a highly debated form of study owing to the emerging proposals of mechanistic implications for exploring the mode of action of ChCs on the virus. Keeping in view the emerging significance of chloroquine derivatives, the present study was performed to screen one hundred and ninety known chloroquine derivatives for their interaction with several SARS-CoV-2 target proteins by molecular docking and molecular dynamics simulations to obtain an in-depth understanding of the potential hits of these compounds against SARS-CoV-2. A total of 190 molecules from the chloroquine family were screened for the identification of potential new inhibitors of the three therapeutic target proteins of SARS-CoV-2, namely Mpro (master protease), PLpro (papain-like protease) and SGp-RBD (spike glycoprotein receptor binding domain). The ChCs bound to SARS-COV-2 Mpro, PLpro, and SGp-RBD were generated by molecular docking and molecular dynamics simulations. Herein, a comparative analysis of chloroquine family products and a well-known drug against SARS-CoV-2, called Remdesivir, has also been presented. This investigation is intended to study the mechanism of interaction between ChCs and the SARS-CoV-2 virus and explore the unprecedented areas associated with the inhibitory activity of ChCs against this virus.

Small and Medium Enterprises (SMEs) play a crucial role in the Indian economy. To remain competitive in the global market, application of Lean Manufacturing Techniques (LMT) helps SMEs to improve their processes in alignment with customer needs. The purpose of this study is to reduce overall lead time by identification and eliminating non-value added activities (NVA) from the manufacturing system. In this paper, the current manufacturing processes have been thoroughly studied using the principle of work study. Several lean approaches such as- TAKT time computation, Value stream Mapping (VSM), layout optimization, Kanban, Andon etc. have been used to make improvement in line efficiency and hence productivity. The study shows that use of line balancing technique, matches the cycle time with calculated TAKT time. And the efficiency of the line has increased approx 10% and hence balance delay got reduced. Again VSM helps to reduce the lead time of foundry shops by 51 minutes. It is one of the few studies that deal with productivity improvement in Indian SME.

Real life inventory lot sizing problems are frequently challenged with the need to order different types of items within the same batch. The Joint Replenishment Problem (JRP) addresses this setting of coordinated ordering by minimizing the total cost, composed of ordering (or setup) costs and holding costs, while satisfying the demand. The complexity of this problem increases when some or all item types are prone to obsolescence. In fact, the items may experience an abrupt decline in demand because they are no longer needed, due to rapid advancements in technology, going out of fashion, or ceasing to be economically viable. This article proposes an extension of the Joint Replenishment Problem (JRP) where the items may suddenly become obsolete at some time in the future. The model assumes constant demand and the items’ lifetimes follow independent negative exponential distributions. The optimization process considers the time value of money by using the expected discounted total cost as the minimization criterion. The proposed model was applied to some test cases, and sensitivity analyses were performed, in order to assess the impact of obsolescence on the ordering policy. The increase in the obsolescence risk, through the progressive increase of the obsolescence rates of the item types, determines smaller lot sizes on the ordering policy. The increase in the discount rate causes smaller quantities to be ordered as well.

This paper reviews context and results of a software tool, named SaTrade, for Model Based System Engineering in System Design of a CubeSat. This tool helps designers to go through system design trade offs easily in System and Subsystem Levels. To achieve this, Modeling for subsystem design has been made using Block Diagram Definitions and implemented in codes with Inputs from System Design and Outputs to Subsystem specifications and Design Integration. Another Feature of SaTrade is change and modification control and management, where it can be from Requirements or other Inputs from System Design or Interfaces. Changes will be affected on the System Design to allow the Designers follow the process by simulations for Integrity check and Evaluation. The first version of SaTrade focuses on Satellite Structure Design and Configuration Management more, using its Neural Network Algorithms dedicated for this purpose, however, it is intended to make paperless automated design available for the whole CubeSat System in the next version.

The aim of this research is to analyze the influence of organizational culture, owner characteristics, government intervention on entrepreneurial orientation and its implications for business performance among MSME actors in the culinary sector in Bogor City, West Java Province, Indonesia. The sample in this study was 196 respondents consisting of MSMEs operating in the food sector that had been running for at least 6 months. Sampling technique using random sampling. Data collected through questionnaires was then analyzed using SEM-PLS. Research findings based on data analysis that have been carried out show that Organizational Culture has a positive and significant influence on the Entrepreneurial Orientation of MSME Actors in the Culinary Sector in the City of Bogor; Owner Characteristics have a positive and significant influence on the Entrepreneurial Orientation of MSME Actors in the Culinary Sector in the City of Bogor; Government intervention has a positive and significant effect on the Entrepreneurial Orientation of MSMEs in the Culinary Sector in the City of Bogor; Organizational culture has a positive and significant effect on business performance among MSME actors in the culinary sector in the city of Bogor; Owner characteristics have a positive and significant influence on business performance among MSME actors in the culinary sector in the city of Bogor; Government intervention has a positive and significant effect on business performance among MSME actors in the culinary sector in the city of Bogor; Entrepreneurial Orientation has a positive and significant effect on Business Performance among MSMEs in the Culinary Sector in the City of Bogor; Organizational Culture has a positive and significant effect on Business Performance through entrepreneurial orientation for MSMEs in the Culinary Sector in Bogor City; Owner characteristics have a positive and significant influence on business performance through entrepreneurial orientation for MSME actors in the culinary sector in the city of Bogor; Government intervention has a positive and significant effect on business performance through entrepreneurial orientation for MSME actors in the culinary sector in Bogor City, West Java Province, Indonesia.

The efficiency of different sorbents (bulk soil, sand, silt, clay and humic acid-HA) for chlorantraniliprole (CAP), dinotefuran (DNF), bispyribac-sodium (BPS), and metribuzin (MBZ) adsorption was described and compared. The adsorption of CAP, DNF, BPS and MBZ were significantly greater on clay and HA fractions than the bulk soils. Also, the tested pesticides sorption was greater on HA fraction compared to clay fraction except in the case of BPS. The mass unit of bulk soil adsorbed of CAP, DNF, BPS and MBZ approximately 15, 20, 10 and 5 % of the same of HA and 40, 60, 95 and 35 % of that of clay fraction, respectively. The actual amounts adsorbed on bulk soil ranged from (88.63 to 93.93 %) of the calculated amounts adsorbed on all soil components indicating high efficiency of the tested soils to adsorb tested pesticides. All adsorption data fitted well to the linear Freundlich equation. The adsorption of tested pesticides in soil and their different constituents is S-type according to 1/n (except some cases).

This paper seeks to examine the relationship between determinants of blood transfusion sustainability (BTS) that is master production scheduling (MPS) and total quality management (TQM) of Uganda. The study was founded on four objectives. The study looked at the direct relationship between MPS and the BTS, direct relationship between MPS and TQM, direct relationship between TQM and BTS. It also assessed how TQM mediated the direct relationship between MPS and BTS. The study used a quantitative method. A survey questionnaire was administered to collect data from 367 staff of regional blood banks and government university teaching hospital blood banks; and 213 were found to be usable. The main analysis was done using structural equation modeling. The study found that MPS had a positive and significant relationship with the BTS. The study found that the relationship between MPS and TQM was positive and significant. The study also found that the relationship between TQM and BTS was positive and significant. The study concluded that the effect of MPS on BTS was not mediated by TQM. It was recommended that blood banks seeking to achieve transfusion sustainability must invest in understanding the sector in which they operate. This includes understanding the blood demand requirement, customer focus, people involvement and timely delivery. The various stakeholders in the blood supply chain i.e. blood banks, hospital blood banks, funding agents, ministry of health, must also integrate to enhance the transfusion sustainability. Blood banks performance measures essentially timely delivery was very critical for saving lives of patients in need of blood. The study has provided a new conceptual framework that investigates the TQM mediating effect on the relationship of MPS and BTS, and thus can serve as an incentive for more research to be conducted in this regard in blood banks of different developing countries. The authors also proposed identifying the effect of other TQM factors such as process management, system management, supplier relationship and top management on BTS.

The selection of an optimal supplier is a critical and open challenge in supply chain management. While experts' assessments significantly influence the supplier selection process, their subjective interactions can introduce unpredictable uncertainty. Existing methods have limitations in effectively representing and handling this uncertainty. The paper aims to address these challenges by proposing a novel approach that leverages q-rung orthopair fuzzy sets (q-ROFSs). The novelty of the proposed approach lies in its ability to accurately capture experts' preferences through the use of q-ROFSs, which offer membership and non-membership degrees, providing a broader expression space compared to conventional fuzzy sets. Additionally, it incorporates social network analysis (SNA) to effectively consider the trust relationships among experts. The proposed approach is divided into three stages. The first stage, presents a novel method to determine experts' weights by combining SNA, the Bayesian formula, and the maximum entropy principle. This approach allows for a more precise representation of varying levels of expertise and influence among experts, addressing the uncertainty arising from subjective interactions. The second stage introduces a hybrid weight determination method to determine criteria weights within the context of q-ROFSs. Entropy plays a crucial role in capturing fuzziness and uncertainty in q-ROFSs, while the projection measure simultaneously provides information about the distance and angle between alternatives. By employing both objective weights estimated using entropy and normalized projection measure and subjective weights derived using an aggregation operator and a score function, the presented approach achieves a comprehensive assessment of criteria importance. To incorporate both subjective and objective weights effectively, game theory is applied which allows us to align decision-making with both quantitative and qualitative aspects, making the method more versatile and applicable. The third stage redefines the traditional Combined Compromise Solution (CoCoSo) method using Bonferroni mean operators which captures interrelationships among arguments to be aggregated. Furthermore, in recognition of the importance of an expert risk preferences and psychological behaviors, we apply regret theory, ensuring that the chosen solutions align more effectively with their underlying preferences and aspirations. The applicability and effectiveness of the proposed approach are demonstrated through a numerical example of green supplier selection. The comparative analysis illustrates the practicality and real-world relevance while the sensitivity analysis, confirms the stability and robustness of the proposed approach.

Crew pairing is the primary cost checkpoint in airline crew scheduling. Because the crew cost comes second after the fuel cost, a substantial cost saving can be gained from effective crew pairing. In this paper, the cockpit crew pairing problem (CCPP) of a budget airline was studied. Unlike the conventional CCPP that focuses solely on the cost component, many more objectives deemed to be no less important than cost minimisation were also taken into consideration. The adaptive non-dominated sorting differential algorithm III (ANSDE III) was proposed to optimise the CCPP against many objectives simultaneously. The performance of ANSDE III was compared against the NSGA III, MOEA/D, and MODE algorithms under several Pareto optimal measurements, where ANSDE III outperformed the others in every metric.