The proposed study of this paper investigates the effects of total quality management (TQM) and eco supply chain management on business sustainability. The type of research used in this research is quantitative research and uses an online questionnaire as a tool to collect data from respondents. Research data was obtained by distributing online questionnaires to 568 Manufacturing company managers who were determined using the simple random sampling method. The questionnaire was designed to contain statement items and the Likert scale used in this research. The data analysis method used in this research was structural equation modelling partial least squares (PLS-SEM) with data processing tools, namely SmartPLS 4.0 software. The findings of this research specify that TQM and eco supply chain management had significant effects on business sustainability. The results of this research indicate that TQM and eco supply chain implementation were manifested in the company's ability to produce high product quality directly affecting the business sustainability of manufacturing companies.