A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.

The article highlights the business process management system in food industry. The subject of the research is the theoretical and practical aspects of managing business processes in the food industry. The authors explain the concept of "business process" and methods for achieving its improvement goals. The author’s scheme for managing business processes in the food industry in the context of economic transformations was developed and implemented. The in-troduction of a process approach requires efforts and resources for identifying business pro-cesses, their analysis, drawing up models of business processes. The analysis of business pro-cesses in the food industry of Ukraine at a macro level is carried out, including: an imperfect tax system; the mechanism imperfection of state and customs tariff regulation of food mar-kets, the low level of financial support from international organizations, the low level of state support for agribusiness entities; decline in employment and rising unemployment; growth in international migration; low competitiveness of Ukrainian food products and barriers to international food trade. Methodical approaches for determining the regional strategic potential of food safety are also proposed. The calculations of the regional potential of food safety are car-ried out using the data of the Black Sea region in Ukraine as an example. The main prerequisites for the formation of a food safety system have been identified and justified. The organization’s transition to clear and efficient processes to achieve the objectives with optimal costs in the food industry; high flexibility and adaptability of the control system, due to the large self-regulation of the system and natural customer orientation; high dynamism of the system and its internal processes, due to the strong vertical integration of resource flows and a common interest in increasing their circulation; simplification of coordination, organization, control procedures and the possibility of deep integrated automation of food production; high motivation in ensuring the production of quality and competitive food is discussed.

This article establishes and grounds the topicality of personal human capital for its development. It proves that the available approaches, methods and models do not consider the business enterprise needs to increase the efficiency of individual employee’s contribution to the formation of market value. Human capital is offered to consider as a function of personal intelligence, which depends on the personal creative, status and social abilities. The adaptation of mathematical tools is conducted to establish intellectual personal characteristics with justification of different variants of their numerical values. The article also completes the evaluation tools by way of questionnaires, tests and personal objective characteristics, and suggests the approaches to the procedure of results evaluation and interpretation. The testing of the mathematical and testing tools of the personal human capital research was conducted with a group of people whose team is as close as possible to a typical industrial staff workers or its structural subdivision. The results of the personal human capital survey allowed us to identify both individual and collective needs in improving the planning processes for its development.

This paper deals with the pressing challenge of raising the level of environmental responsibility of agricultural enterprises in order to ensure their sustainable development. It has long been established that agricultural activity is accompanied by a significant negative anthropogenic impact on the environment. Therefore, globally, the trend is towards the development and implementation of the principles of environmental responsibility of businesses, which contributes to increasing the competitiveness of businesses, and improving product quality and living conditions of the people. The paper suggests that the environmental responsibility of an agricultural enterprise has to be assessed based on key criteria including the intensity of the use of natural and biological resources, the environmental management system, and business’s participation in solving environmental problems of communities. The paper presents the results of the assessment of the level of environmental responsibility of large, medium and small agricultural enterprises of Ukraine. The results suggest that medium and small agricultural enterprises are predominantly at the initial stage of applying the principles of environmental responsibility in their operations. Moreover, the paper presents the findings of a survey aimed to identify major hindering factors to the observance of the principles of environmental responsibility. These factors include the risk of a decreased business profitability, limited financing, lack of knowledge and shortage of professional staff, insufficient guidelines on the incorporation of principles of environmental responsibility. The paper suggests a mechanism for introducing environmental responsibility at agricultural enterprises that encompasses the governmental, local, and organizational levels. To introduce environmental responsibility at the organizational level, the authors recommend developing and implementing corporate green development strategy, incorporating sustainable procurement, training personnel, and engaging in voluntary public reporting on compliance with the principles of corporate social and environmental responsibility.

The purpose of this article is to make an assessment on infrastructure development efficiency based on Data envelopment analysis (DEA) method. The proposed method allows assessing the level of current infrastructure conditions which provides production and social dimension of its stable development. The article substantiates the necessity of conducting an analytical assessment of infrastructure development level which identifies its weaknesses and determines potential of improving its performance indicators. An integral assessment of transport infrastructure efficiency is proposed. To assess the problems of infrastructure development provision, a comparative analyses and ordering the objects according to growth or decrease of the indicators is performed. The results of the research allow discovering the causes of harmful phenomena in the system of management and development, and identifies major trends and prospects of development.

This research aims to improve a methodic for evaluation of economy’s competitiveness through theoretical-methodological substantiation, forming and calculation of integral indices of innovative technological competitiveness across the regions of a country. The relevance and indispensability of reinforcement of economy’s competitiveness on innovative technological foundations are also substantiated. Available methodical approaches in economic literature and competitiveness rankings and indices used by leading international economic organizations, namely in innovations and high technology domains, are generalized. Authors’ methodic of calculation of integral index of economy’s innovative technological competitiveness is suggested. Integral indicators of provision of innovative technological activity with resources, innovative technological activity and efficiency of innovative technological activity across regions (on the example of Ukraine) are calculated for 2009-2018; conclusions regarding the preconditions, capacity and availability of tendencies of innovative technological activity in oblasts (regions) of the country are made. The paper explains that each of the components of innovative technological competitiveness of the country’s economy had almost equal input in forming of its integral index – provision with resources, capacity and efficiency of innovative technological activity. In the first place, it is an additional argument in favor of the model’s reliability, and in the second place, it brings into the fore the importance of public policy in terms of improvement of resources maintenance of innovative and technologically active companies, boosting of innovative technological activity and increasing of its efficiency and contribution to general economic growth of the country. Strategic priorities of state policy of reinforcement of the economy’s innovative technological competitiveness are substantiated.

The purpose of the article is to substantiate an alternative methodology for assessing the com-petitiveness of young people in the labor market, based on the categories of transit from training to decent employment in the context of transformational change. The article explores the School-to-Work Transition Survey (SWTS), which provides an opportunity to analyze the peculiarities of young people's transit to the labor market. The study was conducted within the framework of the “Work4Youth” project, which aimed to identify ways to obtain information concerning the labor market, namely its youth segment. The main purpose of the SWTS was to gather detailed information on the issues, attitudes and conditions in which young people aged 15–29 was entering and securing their jobs in the labor market. The competitiveness of young people in the labor market has been evaluated and the regions have been investigated according to the characteristics of the workplaces, where the state of completion of the transition from school to employment by the young person have been determined. In addition, clusters that are close in characteristics to the group of regions were distinguished.

The article substantiates the essence of the concept of “social capital” as a resource in terms of formed, permanent, established types of highly effective socio-economic interactions. In addition, the main directions of its manifestation and its structural elements are defined. It is stated that for quantitative measurement of social capital at the enterprise level, it is necessary to establish its precise framework, to determine its structure and key features. As an object of accounting, social capital should be regarded as an intangible asset. The expediency of using the Value explorer method for social capital estimation, which requires some necessary steps, has been substantiated as follows: the use of clearly established algorithm of actions in the implementation of rational selection for a new product; the use of internal and external innovations in the process of generating new ideas and production of innovations within the framework of the product realization strategy; identify areas of key competitive advantages related to social capital; determining the role of the sphere of competitive advantages in production and sales of products; gross profit distribution by key competitive advantages; calculation of the potential of the competitive advantages sphere; assessment of the durability and sustainability of the competitive advantages of the enterprise and calculation of the present value of all elements of social capital of the enterprise. Five main levels of social intangibles are identified and grounded. The study allows to form an appropriate matrix to analyze the effectiveness of their use in the enterprise.

This article is devoted to the problems of forming analytical support for the management of economic activities of industrial enterprises under emergency situations. It is established that the current ap-proaches of the formation of economic analysis in economic activities do not allow to fully assess the impact of emergencies on the financial conditions of the enterprises. Therefore, a taxonomic analysis technique is applied, which allows to represent the level of business development mathe-matically and to identify the most influential factors, including the consequences of emergencies. Methodological provisions for the use of taxonomic analysis are also developed, which consist of successive stages of application of analytical procedures for evaluating the development of the enterprise. This includes a comprehensive assessment of the level of development of the enterprise in the context of emergency situations by calculating an integrated taxonomic indicator; assessment of the structure and dynamics of the integrated emergency indicators and the assessment of the consequences of the emergency. The methodology is applied and tested on the example of activity of PAP “Novokramatorsky Automobile-Building Plant”. Overall comprehensive assessment of the level of development of the enterprise allows us to identify advantages, disadvantages and “bottlenecks” in the activity of the enterprise. It also identifies and mobilizes internal economic reserves, optimize the financial and economic activity of the enterprise as a whole, as well as timely diagnose the presence and depth of the crisis. The methodology can be applied at the enterprises of different branches of national economics with different sizes.

In this review we systematized the theoretical and experimental data concerning the versatile approaches for the synthesis of N-acylphenothiazines. The aim of the study was to compile the literature reported worldwide in the past 20 years. This article also reviewed the analysis of pharmacological activities of these heterocycles as one of the promising chemotherapeutic objects for the modern bioorganic and medicinal chemistry. It has been hypothesized that the enormous biological potential of these moieties is due to the radical nature in the acyl moiety. Therefore, the present review will be a good contribution to the literature and will provide the platform for the medicinal chemistry researchers to carry out more studies aiming the N-acylphenothiazine moieties as the novel chemotherapeutic agents.