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Growing Science » Current Chemistry Letters » Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 11 Issue 1 pp. 75-82 , 2022

Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents Pages 75-82 Right click to download the paper Download PDF

Authors: Iryna Myrko, Taras Chaban, Vasyl Matiychuk

DOI: 10.5267/j.ccl.2021.9.003

Keywords: Synthesis, Heterocycles, Pyrazole, 7H-[1, 2, 4]Triazolo[3, 4-b][1, 3, 4]thiadiazines, Antimicrobial activity

Abstract: A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.

How to cite this paper
Myrko, I., Chaban, T & Matiychuk, V. (2022). Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents.Current Chemistry Letters, 11(1), 75-82.

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Journal: Current Chemistry Letters | Year: 2022 | Volume: 11 | Issue: 1 | Views: 1609 | Reviews: 0

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