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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 11 Issue 4 pp. 341-352 , 2022

Experimental study on the interaction of insulin with apatitic calcium phosphates analogous to bone mineral: adsorption and release Pages 341-352 Right click to download the paper Download PDF

Authors: Abdelhadi El Rhilassi, Mounia Bennani-Ziatni

DOI: 10.5267/j.ccl.2022.6.003

Keywords: Apatite, Insulin, Adsorption, Kinetic, Isotherm

Abstract: A series of isoxazole derivatives, 3-aryl-5-[5-(4-nitrophenyl)-2-furyl]-2,3-dihydroisoxazoles (5a-j) were synthesized by cyclocondensation reaction between 1-aryl-3-[5-(4-nitrophenyl)-2-furyl]prop-2-en-1-ones (4a-j) and hydroxylamine hydrochloride in presence of sodium acetate in glacial acetic acid at reflux temperature. Formerly, compounds (4a-j) were synthesized by the condensation of 5-(4-nitrophenyl) furan-2-carbaldehyde (3) with various aromatic ketones by using alkali as catalyst. The structures of the synthesized various isoxazole have been characterized by using elemental analysis, Infrared,1H-NMR spectroscopy and further supported by Mass spectroscopy. All the products have been screened for their in-vitro biological assay like antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40 µg/ml. It was exposed that the compounds 5a, 5c, 5e, 5f, and 5i showed inspiring antibacterial and antifungal activity compared to the used reference standard.

How to cite this paper
Rhilassi, A & Bennani-Ziatni, M. (2022). Experimental study on the interaction of insulin with apatitic calcium phosphates analogous to bone mineral: adsorption and release.Current Chemistry Letters, 11(4), 341-352.

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Journal: Current Chemistry Letters | Year: 2022 | Volume: 11 | Issue: 4 | Views: 986 | Reviews: 0

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