In the present work, we have discussed the synthesis of a series of 1-((2'-(2-(2-(substitutedphenyl))-2-oxoethyl)-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)piperidine-4-carboxylic acid derivatives by the reaction of 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)piperidine-4-carboxylic acid with phenacyl bromides using potassium carbonate. The structures of synthesized derivatives have been characterized using different spectroscopic techniques like FT-IR, ¹H-NMR, ¹³C-NMR, and Mass. Synthesized compounds were screened for their antibacterial and anti-TB activities all the compounds have found better activity against selected pathogenic strains. In addition, in silco molecular docking studies were carried out on targeted enzymes DNA gyrase and 3-oxoacyl-ACP reductase with ADME-toxicology studies.

Life insurance is designed to reduce the risk of financial loss due to unforeseen consequences related to the insured's death. In life insurance, the insurer provides death benefits as a claim when the insured suffers death. The claim is the compensation for a risk loss. Individual claim in one-period insurance is called aggregation claim, while aggregation claim is a collective risk. Collective risk is usually measured using a variance. However, the variance risk measure cannot often accommodate any event risk because there is a risk of claims beyond the amount of variance. Using the proposed method CVaR and confidence level are taken from α = 0.25% until 4%. This study found that the proposed method CVaR scored more fairly than Collective Risk. In conclusion, this study indicated that the collective risk model is just included using mean and variance without any confidence level. Therefore, only one result for the Collective Risk model, which automatically shows the model using mean, variance and standard deviation, could not accommodate all risk events.

It is not a secret that road accidents cause significant suffering. Those accidents can last from wounded to dead people, negatively impacting a country. A bunch of recent investigations tried to tie road accidents with the quality of roads. Therefore, in a country with a significant infrastructure gap, it is necessary to analyze the relationship between the different kinds of roads and the severity of car accidents. The current research examined such a relationship by employing the Multi logit regression. It was found that the significance of different car accidents will vary among the road types. Moreover, with the help of probability analysis, it was discovered that speeding, emergency services availability, and road security seemed to have a crucial impact on road accidents.

The dynamics of the conflict in the South China Sea (SCS) have begun to enter a new chapter. Currently, the South China Sea (SCS) is a flashpoint in the Asia Pacific region. This study aims to provide an analysis of the concept of the Revolution in Military Affairs (RMA) strategy by the Indonesian Armed Forces (TNI) toward Competitive Advantage in the South China Sea region. This study employed an analytical approach with a qualitative sequence exploratory method supported by some quantitative data. PEST (Political, Economy, Socio-cultural, Technology) analysis and SWOT analysis methods were used to support the study. Furthermore, this study also utilized an Analytical Hierarchy Process (AHP) method approach to provide strategic value and sensitivity analysis as a strategy scenario analysis toward competitive advantage. Based on the results of the research analysis, a strategy under the development of Indonesian Armed Forces capabilities towards a competitive advantage in the South China Sea was obtained, namely the WO strategy which consists of 6 substrate aspects with eight subfactors, namely the combination of all components and strengths in handling security disturbances in the South China Sea (0.162), increased competence of human resources (0.159); development of integrated defense forces and capabilities (0.147), protection of information systems and state secrets (0.145), development of defense facilities and infrastructure (0.109), increasing the capacity and capability of modernizing intelligence technology (0.093), utilization and capacity building of the national defense industry (0.089), deployment of Indonesian Armed Forces troops in the South China Sea (0.075). This study is expected to contribute to the strategy for handling conflicts in the South China Sea and provide strategic steps in increasing capabilities on competitive advantage.

A novel 1,3,4-thiadiazole containing 2-iminothiazolidine-4-ones 4a-b were synthesized through the reaction of 2-chloro-N-(5-ethyl/allylsulfanyl-[1,3,4]thiadiazol-2-yl)-acetamides 1a-b with ammonium thiocyanate in dry acetone. Condensation of 4a-b with various carbonyl compounds according to the standard Knoevenagel procedure yielded the corresponding 5-arylidene- (5a-d), 5-heterylidene- (6a-c), 5-isatinylidene- (7a-b) and 5-(3-phenyl-2-propene-1-ylidene)- (8a-b) derivatives. All the newly synthesized compounds were confirmed by their elemental analysis and spectral data. Synthesized compounds 4a, 5a, 5b, 6a, 6c and 7a were screened for their in vitro antitrypanosomal activity against T. brucei gambience (Feo strain). The 5-ylidene substituted compounds with S-allyl group in position 5 of thiadiazole cycle (5a, 5b, 6a and 7a) displayed good to excellent antitrypanosomal potency with a range IC50 = 7.3-12.8 µM.

The regioselectivity of the [3+2] cycloaddition reactions between trans-β-nitrostyrene and C,N-diarylnitryle imine analogues as three atom components (TACs) has been studied with the use of Conceptual Density Functional Theory in the framework of Molecular Electron density Theory. Global and local reactivity indices were determined. Presented quantum-chemical computations showed that, for the reaction of nitroalkene with diphenylnitryle imine, the most favourable reaction path is determined by the nucleophilic attack of C3 carbon atom of TAC on an electrophilic C_α carbon atom of nitroalkene. Therefore, the creation of 1,3,4-triphenyl-5-nitro-Δ²-pyrazoline, according to channel B, is more probable. Similarly, to presented conclusion, for reactions of nitroalkene with nitryle imines containing ED group at para position of the phenyl ring also the most favourable reaction paths run through channel B leading to 1,3,4-triphenyl-5-nitro-Δ²-pyrazolines. In turn, reactions of nitroalkene with nitryle imines containing EW group at para position of the phenyl ring have the opposite preference and the most favourable reaction paths is channel A leading to 1,3,5-triphenyl-4-nitro-Δ²-pyrazolines.

The objective of this research was to evaluate the effects of public debt sustainability on economic growth in the period 2000-2021 and establish a new optimal debt level that does not affect Peru's economic growth. The general method used to determine this effect was the hypothetical deductive method with a non-experimental and longitudinal trend design, because the data to be analyzed are variations that have occurred over time; the VAR (vector autoregressive) model was used as a specific method, because the evidence was insufficient to consider the simultaneity between the reactions of the variables to propose an SVAR model. Data were collected from economic portals such as the Ministry of Economy and Finance (MEF), as well as the Central Reserve Bank of Peru (BCRP). The estimated sample size was 88 observations representing all quarters from 2000 to 2021. As a result of the econometric regression, the impact of the level of public debt on economic growth is positive, since a one-unit increase in the percentage of public debt will increase the variation of GDP by almost 1.1%. Regarding the debt level forecast and according to the projection made, it was determined that the new debt level that does not affect the sustainability of public finances or the long-term economic growth of the Peruvian economy should be 38% of GDP.

The food industry consumes large amounts of water although there is an increasing demand for water and a rapid decrease in the level of natural water resources. Wastewater resulting from food industries needs to be assessed for their compliance to standards. In this study, wastewater treatment steps from the food industry were investigated for accurate assessment of wastewater loading by analyzing parameters of the concentration of compounds present in the effluents. The results revealed that the parameters of treated wastewater were as follow, electrical conductivity 2931 μs/cm, total suspended solids 100 mg/L, biochemical oxygen demand 90 mg/L, chemical oxygen demand 250 mg/L, total phosphorus 7.9 mg/L, and total nitrogen 70 mg/L. This exerts a huge load on the biological treatment unit. Thus, this study offers an understanding and support in selecting appropriate treatment for industrial wastewater to obtain an effluent suitable in compliance with standards of the environmental quality.

Pulvinaria tenuivalvata (Newstead) (Hemiptera: Coccidae) red soft scale insect is one of the most prevalent insect pests that attacks sugarcane plants. Insecticidal efficiency of six selected insecticides (Malatox, Sulfar, Admiral, Nomolt, Tafaban and Biover) was evaluated for their impact against nymphs and adult females of P. tenuivalvata on sugarcane leaves using leave dipping methods. This investigation was carried out for two successive seasons (July 2021-2022) at the laboratory of the Plant Protection Research Department at the El-Mattana Agricultural Research Station, Luxor Governorate, Egypt. Obtained results showed that the tested insecticides varied in efficacy on the different stages of pest (nymphs and adult females). Moreover, the nymphal stage of P.tenuivalvata was more susceptible to the tested pesticides compared to the adult stage. Admiral and nomolt were the most toxic against the nymphal and adult female stages of P. tenuivalvata on sugarcane leaves, sulfar, however, was the least successful in controlling this pest.

Vehicle routing problem (VRP) is a classic problem studied in logistic. One of the most important variations within this problem is called Green Vehicle Routing Problem (GVRP), in which environmental aspects are considered when designing product delivery routes. This variant arises due to the high levels of pollution produced by transport vehicles, so it is a variation whose study represents a vital impact nowadays. This project will consider a GVRP and will be developed considering the characteristics of multi-depot (MDVRP) and multi-product (MPVRP) to minimize the costs of assignation of vehicles and CO2 emissions. To solve the problem, this project proposes a hybridization between the classic tabu search (TS) metaheuristic and the PAES algorithm (TS+PAES) to generate the Pareto frontier of both objectives. An integer mixed linear programming model is formulated and developed for each objective function separately to have an optimal point of comparison for the efficiency of the proposed algorithm. Also, the TS+PAES algorithm is compared to the nearest neighbor algorithm for large instances. Two computational experiments were carried out, one for small and the other one for large instances. The experiment for small instances showed that the GAP of each extreme of the frontier compared to the MILP model is on average 0.73%. For large instances, the metaheuristic improves in 0.1% the results presented by the MILP model showing that the metaheuristic provides closer near-optimal solutions in less computational time. Besides, the metaheuristic, in comparison with the nearest neighborhood heuristic, improves in 44.21% the results of emissions and in 3.88% the costs. All these results demonstrate the effectiveness of the metaheuristic.