Selective oxidation of primary and secondary alcohols to the corresponding aldehydes and ketones was achieved efficiently using K2S2O8/activated charcoal system. All reactions were carried out at solvent?free conditions (40?45 ?C) within 15?60 min to give the products in high to excellent yields.
Imines of six new quinolin-5-ylamine derivatives 3(a-c) and 5(a-c) were synthesized by the reaction of quinolin-5-ylamine (1) with different aldehydes 2(a-c) and ketones 4(a-c). The chemical structures of the compounds were confirmed by UV-visible, FT-IR and 1H NMR spectral study. New compounds were screened for the antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Butylated Hydroxytoluene (BHT) was used as standard. All the compounds showed DPPH radical scavenging activity, where compound 3c was the best radical scavenger.
2,4,5-Trisubstituted imidazoles have many pharmaceutical properties and can be prepared via reaction of 1, 2-diketones with aldehydes in the presence of an acidic catalyst. In this work, we have prepared 2,4,5-trisubstituted imidazoles in the presence of trichloromelamine as a source of positive chlorine. Short reaction times, high yield, simplicity of operation and easy work-up are some advantages of this method.