A series of (E)-1-methyl-3-((substituted phenylimino)methyl)quinolin-2(¹H)-one schiff bases (3a-j) bearing quinoline moiety synthesized successfully in ethanol by condensation of starting material 1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (1) with various substituted anilines (2a-j). The structure of the newly synthesized compounds was confirmed by proton (¹H) and carbon (¹³C) nuclear magnetic resonance spectroscopy, Fourier transformation infrared (FT-IR), Mass spectroscopic study and elemental analysis. The in-vitro antimicrobial activity of the synthesized compounds was undertaken by agar well diffusion method against gram positive bacteria (Bacillus licheniformis and Bacillus cereus) gram negative bacteria (Escherichia coli and Acetobactor sp.) and antifungal activity against (Aspergillus Flavus and Pichnanomala). Further the compounds which shows good activity (3b, 3c, 3d, 3f, 3g and 3j) are screened for in-vitro antitubercular activity by Micro-plate alamar blue assay (MABA) method against mycobacterium tuberculosis H37Rv strain provided important information about activity against these strains. The structure activities of the synthesized compounds were also discussed. Compounds 3a, 3c, 3d, 3f and 3g show good argument with the different substituent attached to the phenyl ring.

Condensed bicyclic systems with thiadiazole core being annelated to other five-membered heterocycles such as 1,3-thiazole, imidazole or 1,2,4-triazole occupy prominent place in medicinal chemistry because of their broad spectrum of pharmacological activities. The combination of several heterocycles into a bicyclic system commonly provides much more interest in the enhanced activity profile of its analogs than their parent separate constituents. In this review, we summarized the literature data about the main approaches for obtaining and possible directions of structural modification of the most common 1,3,4-thiadiazole containing [5+5] annelated heterosystems as promising objects for modern medicinal chemistry.

The world surrounded by plastics generates a lot of uncertainty and the first victims are sea animals, plastic in contact with the sun is able to disintegrate and generate toxins that are harmful to health. It is for this reason that this research in bibliographic review allows us to know the different solutions to counteract microplastics through the analysis of the Scopus database and the VOSviewer tool that allows us to analyze the data, considering the essential characteristics that are plants, animals, bacteria, algae and technologies that allow the disintegration, elimination and purification of microplastics, graphs and tables were obtained which allow us to recognize the analyzed data, the countries that carry out these investigations and the bibliometric maps worldwide. The results allow us to understand that the existence of microplastics generates many negative consequences for planet earth, however, there are different solutions which we can use and apply to counteract these microplastics, also considering that countries like Peru do not find published scientific research relevant to this matter. The purpose of this research is to allow us to make better decisions and not lose heart in the face of microplastics since it can be fought with the different solutions that we find on planet earth, technology and the other objective is to motivate readers to take action in the issue and allow generating change in the use of plastics.

The adsorption properties of hydroxyapatite of low crystallinity towards methionine have been examined. The chemical composition of hydroxyapatite was taken as an experimental variable in order to have a point of view on the parameters of the adsorption process and the mechanisms established between adsorbent-adsorbate. The adsorption kinetics are relatively fast, and the high amounts adsorbed at saturation are obtained for non-stoichiometric hydroxyapatite, containing more HPO4^2- ions and having a high specific surface area. The good agreement of the experimental data with kinetic models confirms that the mechanism can be perfectly described by pseudo-second-order kinetics. Adsorption isotherm models show that Langmuir's model gives a better fit of experimental data compared to that of Freundlich, Temkin and Dubinin-Kaganer-Radushkevich. Fourier transform infrared spectroscopy confirmed the interaction between the -COO^- ions of methionine and the Ca²⁺ ions of hydroxyapatite. The thermodynamic parameters, the isoelectric point of methionine and the point of zero charge of hydroxyapatite with different Ca/P ratios show that the adsorption process is considered spontaneous, exothermic and often controlled by physisorption with interactions electrostatic.

In today's competitive business environment, the implementation of Customer Relationship Management (CRM) strategies is essential for firms to succeed. The purpose of this study is to investigate the relationship between CRM, customer satisfaction, and business profitability in the Jordanian logistics industry. Specifically, the study examines how customer satisfaction mediates the effect of three key CRM on business profitability. To achieve this, Partial Least Squares Structural Equation Modeling (PLS-SEM) was used to analyze data collected from 384 employees of logistics firms in Jordan. The results of the study suggest that CRM positively affects customer satisfaction, and that customer satisfaction has a significant mediating effect on the relationship between CRM and business profitability. The findings of this study have important implications for logistics firms seeking to improve their business profitability through the adoption of CRM. By focusing on the three key CRM (Customer Identification, Customer Acquisition, and Customer Analytics), firms can improve their customer satisfaction levels, which, in turn, can lead to improved business profitability. This study adds to the growing body of literature on CRM practices and their impact on business profitability, particularly in the context of the Jordanian logistics industry.

The current research addresses the inventory classification problem of community pharmacies, which have a dual role as both a vital component of the pharmaceutical supply chain and a typical retail store. Despite the existing literature indicating that pharmacists may lack knowledge on inventory management, it seems that the MCIC literature is weak in explaining how pharmacists can benefit from MCDA techniques in all aspects. To bridge this gap, the study aims to demonstrate that pharmacists can utilize MCDA techniques to gain deeper insights beyond mere classification in the context of inventory management. Real-world data from a community pharmacy in Turkey was classified using the EDAS method. Sensitivity analysis was performed for MCDA inputs, about which pharmacists may lack information. Scenario findings based on criterion weights and threshold values offer important managerial implications for pharmacists. This study provides a critical contribution to the literature on inventory management in community pharmacies by highlighting the potential of MCDA techniques to support decision-making beyond mere classification. The sensitivity analysis also sheds light on areas where pharmacists may lack knowledge and suggests ways to address these gaps. Overall, the study underscores the need for pharmacists to have a deeper understanding of inventory management and highlights the potential benefits of MCDA techniques in addressing this challenge.

In the present work, Zn, Cu monometallic and bimetallic nanoparticles were synthesized using leaves extract of Borassus flabellifer. Plant extract acts as both surfactant and reducing agent. The synthesized nanoparticles were characterised by UV-Vis, XRD, FESEM, EDX, and HRTEM techniques. UV-Vis spectroscopy is used to monitor the synthesis of nanoparticles. XRD technique was used to confirm the amorphous nature of nanoparticles. The FESEM images demonstrate that the shape of the nanoparticles such as Zn monometallic (pseudo-spherical), Cu monometallic (rod), Zn-Cu bimetallic are (pseudo-spherical and rod-shaped). HRTEM images show the approximate size of the Zn, Cu monometallic and Zn-Cu bimetallic nanoparticles is 3.0 nm, 3.52 nm and 2.2 nm respectively. EDX spectra confirm the presence of Zn, Cu and O in the sample. Synthesized Zn, Cu monometallic nanoparticles, and Zn-Cu bimetallic nanoparticles were used to evaluate their possible antimicrobial, antidiabetic and antioxidant properties. Bimetallic nanoparticles displayed higher antioxidant, antidiabetic, and antimicrobial properties in the comparison of monometallic nanoparticles. The results suggest that Zn-Cu bimetallic nanoparticles have greater potential than monometallic nanoparticles.

The MEWMA chart is one of the traditional multivariate charts which are widely employed in inspecting the quality of manufacturing and services. This chart is created through monitoring the small shifts of mean vectors of variable quality characteristics. Often in practice, the measurement of a quality characteristic produces uncertain, incomplete values, so that ambiguous numbers are obtained. In this condition, a neutrosophic-based control chart can overcome the problem resulting from the ambiguous data. The paper’s objective is to construct a new multivariate monitoring scheme based on a neutrosophic chart, namely the neutrosophic Multivariate EWMA (NMEWMA). Furthermore, the performance of the new multivariate monitoring scheme is evaluated in detecting process shifts employing the Average Run Length (ARL) and Standard Deviation Run Length (SDRL). This control chart is an innovation in the quality monitoring of uncertain data. The research result obtained indicates that the NMEWMA chart performs better than the MEWMA in finding the small mean shifts as well as in the real case application.

In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.

Nanomaterials have attracted a great deal of attention from the scientific community due to their unique properties and applications. The small size metal oxides have opened up the door for intensive research to utilize their properties for biomedical applications. Silver nanoparticle (AgNPs) and metal oxide nanomaterials like MgO, ZnO, NiO and its silver doped nanocomposites (Ag-MgO, Ag-ZnO, Ag-NiO) have been prepared using solid state combustion method using polyvinyl alcohol (PVA) as a fuel. The structure of as prepared oxides and its silver doped nanocomposites were characterized using X-ray diffraction (XRD) tool and morphology by Scanning Electron Micrograph (SEM) tool as well as Transmission electron micrograph tool respectively. Presence of the metals in the oxides and its Ag composite was confirmed by the EDX pattern. Bonding nature in the composite is well studied by the Fourier transform infrared (FT-IR) tool. Antibacterial activity studies of the nanocomposites are carried out against various bacteria.