Flow shop scheduling problems with rudimentary criteria of minimum makespan are the most important investigated problems in the field of scheduling. Generally during the process of generating an optimal sequence, multiple partial sequences claiming the optimal value of makespan are observed. In this paper a novel tie-breaking rule to select one of the best optimal sequences out of all possible partial sequences is developed which then applied to Nawaz-Enscore-Ham (NEH) heuristic to solve the scheduling problems in permutation flowshop without increasing the computational complexity. The performance of proposed heuristic is tested with other existing tie-breaking heuristics of similar complexity over Taillard and VRF's instances. Computational results reveal that in terms of solution quality, the proposed heuristic outperforms over the other NEH based heuristics of the same complexity reported in literature.

The development of the Islamic State (IS) in Southeast Asia creates changes in the social order in a direct and indirect manner. This study aims to identify the factors that influence the development of the Islamic State (IS) and analyze the influence of its development on social vulnerability in Southeast Asia. This study employed a mixed-method supported by the Interpretive Structural Modeling (ISM), Analytical Hierarchy Process (AHP), and System Dynamics (SD). Based on the results of research from relevant experts, this study uncovered seven the most dominant and structured problems. Furthermore, there are fourteen elements related to the social vulnerability of the Islamic State (IS) in Southeast Asia. The social vulnerability value is 0.01 and is categorized as Low Vulnerability. The aspects that influence the development of Islamic State indicate that the existing social system in Southeast Asia is strong enough in encountering the influence of ideology and the development of the Islamic State.

Sulfonamides are a very good antibacterial agent that targets essential bacterial enzymes specifically DNA gyrase. The objective of the present work was to investigate the molecular docking of the (4-(tert-butyl)-N,N-diethylbenzenesulfonamide) with the DNA gyrase of S. aureus. The energy-free topoisomerase activity of the A subunit, which breaks the DNA, is inhibited by 4-quilones such as nalidixic acid and ciprofloxacin. The energy transducing activity of the B subunit is inhibited by novobiocin and other coumarin antibiotics. Single crystal X-ray diffractometer study was carried out to understand the structure, physical and chemical reactive parameters, the title compound is crystallized under monoclinic crystal system with the space group of P21/C. To understand the behaviour of the title compound in living organism, Absorption, Distribution, Metabolism, Excretion analysis was done using Swiss ADME and Osiris data warrior tool. Further, Toxicity of the title compound was predicted by using PKCSM online software.

Many real-world problems in manufacturing system, for instance, the scheduling problems, are formulated by defining several objectives for problem solving and decision making. Recently, research on dispatching rules allocation has attracted substantial attention. Although many dispatching rules methods have been developed, multi-objective scheduling problems remain inherently difficult to solve by any single rule. In this paper, a hybrid genetic-based gravitational search algorithm (GSA) in weighted dispatching rule is proposed to tackle a scheduling problem by achieving both time and job-related objectives. Genetic algorithm (GA) is used to select two appropriate dispatching rules to combine as a weighted multi-attribute function, while the GSA is used to optimize the contribution weightage of each rule in each stage of the flow shop. The results show that the proposed algorithm is significantly better than the traditional dispatching rules and the rules allocation algorithm. The proposed algorithm not only improved the quality of the schedule in multi-objective problems but also maintained the advantages of traditional dispatching rules in terms of ease of implementation.

In this study, under the carbon cap-and-trade mechanism, the ordering cost presents a stepwise function for ordering quantity, and the optimal economic ordering quantity model aims to explore the manufacturer's total cost minimization in the finite planning horizon, in combination with the actual situation that the product will produce carbon emissions during transportation and storage. The economic order quantity (EOQ) model with stepwise ordering cost is applicable to the decision environment in which goods are utilized by sea, by rail or by air (e.g., the order cost is charged in addition to the basic fixed cost, the importer of raw materials will pay an additional freight related to delivery, such as the rent for the use of container numbers.). A heuristic algorithm is also proposed to analyze the relevant properties of the optimal solution of the model and to solve the optimal order times and quantities of the manufacturer under the constraint of carbon policy.We further compared the optimal order times with the case without carbon constraint and the order times corresponding to the manufacturer's realization of the minimum carbon emission, and obtained the conditions for the manufacturer to achieve low cost and low emission under the carbon policy.Finally, the theoretical results of the model are verified by numerical examples,and the influence of relevant parameters on the inventory strategy of manufacturers is discussed. The results show that under the carbon cap-and-trade policy, there is an optimal ordering strategy that minimizes the total cost of the manufacturer in the finite horizon. When the demand of the manufacturer is under finite horizon and the carbon policy is equal to the specific multiplier of orders, the manufacturer can achieve a win-win result of low cost and low emissions.

Finding the locations of departments or machines in a workspace is classified as a Facility Layout Problem. Good placement of departments has a relevant influence on manufacturing costs, work in process, lead times and production efficiency. This paper analyses the problem of allocating departments with restrictions in terms of unequal area and rectangular shape within a facility, in order to minimize the sum of material handling costs taking into account the satisfaction of the aspect ratio requested. In particular, we propose for the first time a Firefly Algorithm based on the slicing structure encoding. The proposed method was tested comparing the results obtained from other authors on the same literature instance. The results confirm the effectiveness of the Firefly Algorithm in solving the Facility Layout Problem by generating the best solutions with respect to those provided by previous researches.

As the most contributed sectors in agriculture, rice farming is facing various risks, namely uncertainty such as crop failure caused by climate change, including air temperature, weather, rainfall and others. Indonesia is categorised as an agricultural country with a tropical climate. By this season, the farmers can plant the rice. Rice farming is currently an inseparable part of most agricultural societies in Indonesia, especially in West Java. However, changes in air temperature, weather and annual rainfall, can increase the uncertainty and upward the risk of crop failure. Thus, the current study seeks to investigate the decision making for agricultural risk assessment (climate variable) through the formulation of a risk model for agricultural insurance in Indonesia. This study utilised the climate variables, which consist of air temperature, wind speed, maximum and minimum temperatures, and rainfall. For determining the magnitude of risk, we applied the Block Maxima method and Peak Over Threshold. The results of this study found that the highest risk of losses occurred in November, December, January, February and March with a value of 0.17485.

Already faced with tight competition and low profit margins, the airline industry is going through major changes in the wake of the current pandemic resulting in travel restrictions and slump demands, prompting airlines to curtail services and investments in every aspect of business. To that end, developing a comprehensive method of improving airline performance measures is crucial. However, this type of problem is complex to solve due to a large number of factors, requiring a systematic approach. It entails taking into account a multitude of conflicting, or sometimes interrelated criteria, hence becoming an inherently multiple criteria decision making problem. This study is aimed to assess the competitiveness of airlines and evaluate their financial and operational performances in relation to such criteria. We test FAHP, TOPSIS, and a hybrid method of combining FAHP and TOPSIS methods. In particular, regarding the hybrid method, FAHP is employed to determine the influential weights of criteria that are utilized in TOPSIS for preference values among alternatives. We demonstrate the applicability of the proposed methods to solving a MCDM problem of airline performance assessments using real data sets. Further, this study focuses on examining the relationship between financial and operational performance criteria, as well as gleaning insights for airlines to build an evaluation system that would aid in understanding their strength and weakness in the performance metrics. The computational experiment results of our hybrid FAHP-TOPSIS model support the efficacy of incorporating fuzzy values concerning influential weight criteria. By judiciously distributing criteria weights that are specific to the airline industry, our proposed model captures preference scores reflective of industry-related and concurrent measures. This modeling framework can help airlines better evaluate the systematic influential relation structure among criteria in critical financial and operational dimensions.

In this article, a hybrid algorithm is proposed to solve the Vehicle Scheduling Problem with Multiple Depots. The proposed methodology uses a genetic algorithm, initialized with three specialized constructive procedures. The solution generated by this first approach is then refined by means of a Set Partitioning (SP) model, whose variables (columns) correspond to the current itineraries of the final population. The SP approach possibly improves the incumbent solution which is then provided as an initial point to a well-known MDVSP model. Both the SP and MDVSP models are solved with the help of a mixed integer programming (MIP) solver. The algorithm is tested in benchmark instances consisting of 2, 3 and 5 depots, and a service load ranging from 100 to 500. The results obtained showed that the proposed algorithm was capable of finding the optimal solution in most cases when considering a time limit of 500 seconds. The methodology is also applied to solve a real-life instance that arises in the transportation system in Colombia (2 depots and 719 services), resulting in a decrease of the required fleet size and a balanced allocation of services, thus reducing deadhead trips.

A new approach is applied in the process of measuring the efficiency of decision-making units (DMUs) through the cross-efficiency evaluation method. Ideal and Anti-Ideal models are generated to form a comprehensive method based on the cross-efficiency evaluation method. The two models are formulated and combined to the Data Envelopment Analysis using the CRITIC method. In a comparative analysis based on three numerical examples, the proposed approach can lead to achieving a more reliable result than one based on an individual method.