In this work, the indirect reductive amination of terephthalaldehyde with aqueous ammonia was studied. The condensation of terephthalaldehyde with ammonia afforded a new compound containing two aldehyde groups (CHO), one imino group (C=N), and an aminal carbon (N–CH–N). Reaction of this compound with sodium borohydride resulted in the reduction of the aldehyde groups, the imino carbon, and the aminal carbon. Analysis of the condensed Fukui functions and the LUMO orbital allowed us to propose a mechanism that explains this reactivity. Furthermore, a general mechanism for the condensation of aromatic aldehydes with aqueous ammonia is presented.

A new series of 4-amino-4H-1,2,4-triazole derivatives, 3a-f and 5a-f were synthesized by using various aryl aldehydes and ketones. FT-IR, ¹H NMR, ¹³C NMR and mass spectral studies were characteristic of the synthesized compounds. These new compounds were screened in male wistar rats and compared with the standard drug for their anticonvulsant activity against maximal electroshock seizure (MES) model. Compounds 3b and 5d of this sequence were found to be the most active. The same compound did not demonstrate neurotoxicity at the administered maximum dose (100 mg / kg) and these compounds showed good protection compared to other compounds.

A Convenient and green synthesis of 4H-pyran derivatives via one-pot multicomponent reaction of aromatic aldehydes, malononitrile and ethyl acetoacetate using KOH loaded CaO as a catalyst under solvent free condition is reported. The morphology of the catalyst has been characterized by XRD and TEM. This protocol have numerous advantages like lesser reaction time, environment friendly, low cost, easy to separate, and provide higher yield. The synthesized compounds have been characterized and confirmed by different spectroscopic techniques like ¹H NMR, ¹³C NMR, FT- IR, and LC- MS.