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How to cite this paper
APA: Danyliuk, I., Kemskyi, S., Saliyeva, L., Slyvka, N., Melnyk, D., Melnyk, O., Dorokhov, V & Vovk, M. (2025). Antioxidant activity, DFT-calculation, and docking of 5-amino-N-(3-di(per)fluoroalkyl-2-iodo-n-propyl)-1,2,3-triazole-4-carboxamides. Current Chemistry Letters, 14(2), 251-264.
Chicago/Turabian: Danyliuk, I., Kemskyi, S., Saliyeva, L., Slyvka, N., Melnyk, D., Melnyk, O., Dorokhov, V & Vovk, M. 2025. "Antioxidant activity, DFT-calculation, and docking of 5-amino-N-(3-di(per)fluoroalkyl-2-iodo-n-propyl)-1,2,3-triazole-4-carboxamides." Current Chemistry Letters 14, no. 2 (2025): 251-264.
AMA: Danyliuk, I., Kemskyi, S., Saliyeva, L., Slyvka, N., Melnyk, D., Melnyk, O., Dorokhov, V & Vovk, M. Antioxidant activity, DFT-calculation, and docking of 5-amino-N-(3-di(per)fluoroalkyl-2-iodo-n-propyl)-1,2,3-triazole-4-carboxamides. Current Chemistry Letters. 2025;14(2):251-264.
References
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2. Motornov V., and Beier P. (2023) NH-1,2,3-Triazoles as Versatile Building Blocks in Denitrogenative Transformations. RSC Adv., 13 (49) 34646-34653 (https://doi.org/10.1039/D3RA06045D).
3. Shiri P., Amani A.M., and Mayer-Gall T. (2021) A Recent Overview on the Synthesis of 1,4,5-Trisubstituted 1,2,3-triazoles. Beilstein J. Org. Chem., 17 1600-1628 (https://doi.org/10.3762/bjoc.17.114).
4. Reddy G.S., Anebouselvy K., and Ramachary D.B. (2020) [3+2]-Cycloaddition for Fully Decorated Vinyl-1,2,3-Triazoles: Design, Synthesis and Applications. Chem. Asian. J., 15 (19) 2960-2983 (https://doi.org/10.1002/asia.202000731).
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1. Vala D.P., Vala R.M., and Petel H.M. (2022) Versatile Synthetic Platform for 1,2,3-Triazole Chemistry. ACS Omega, 7 (42) 36945-36987 (https://doi.org/10.1021/acsomega.2c04883).
2. Motornov V., and Beier P. (2023) NH-1,2,3-Triazoles as Versatile Building Blocks in Denitrogenative Transformations. RSC Adv., 13 (49) 34646-34653 (https://doi.org/10.1039/D3RA06045D).
3. Shiri P., Amani A.M., and Mayer-Gall T. (2021) A Recent Overview on the Synthesis of 1,4,5-Trisubstituted 1,2,3-triazoles. Beilstein J. Org. Chem., 17 1600-1628 (https://doi.org/10.3762/bjoc.17.114).
4. Reddy G.S., Anebouselvy K., and Ramachary D.B. (2020) [3+2]-Cycloaddition for Fully Decorated Vinyl-1,2,3-Triazoles: Design, Synthesis and Applications. Chem. Asian. J., 15 (19) 2960-2983 (https://doi.org/10.1002/asia.202000731).
5. Agouram N., El Hadrami E.M., and Bentama A. (2021) 1,2,3-Triazoles as Biomimetics in Peptide Science. Molecules, 26 (10) 2937 (https://doi.org/10.3390/molecules26102937).
6. Li W., and Zhang J. (2020). Synthesis of Heterocycles through Denitrogenative Cyclization of Triazoles and Benzotriazoles. Chemistry, 26 (52) 11931–11945 (https://doi.org/10.1002/chem.202000674).
7. Slavova K.I., Todorov L.T., Belskaya N.P., Palafox M.A., and Kostova I.P. (2020) Developments in the Application of 1,2,3-Triazoles in Cancer Treatment. Recent Pat Anticancer Drug Discov., 15 (2) 92-112 (https://doi.org/10.2174/1574892815666200717164457).
8. Forezi L.S.M., Lima C.G.S., Amaral A.A.P., Ferreira P.G., Souza M.C.B.V., Cunha A.C., da Silva F.C., and Ferreira V.F. (2021) Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications. The Chemical Record, 21 (10) 2782-2807 (https://doi.org/10.1002/tcr.202000185).
9. Poonia N., Kumar A., Kumar V., Yadav M., and Lal, K. (2021) Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents. Curr. Top. Med. Chem., 21 (23) 2109-2133 (https://doi.org/10.2174/1568026621666210913122828).
10. Alam M.M. (2022) 1,2,3-Triazole hybrids as anticancer agents: A review. Arch Pharm., 355 (1) e2100158 (https://doi.org/10.1002/ardp.202100158).
11. Ravindar L., Hasbullah S.A., Rakesh K.P., and Hassan, N.I. (2023) Triazole Hybrid Compounds: A new Frontier in Malaria Treatment. Eur. J. Med. Chem., 259 115694 (https://doi.org/10.1016/j.ejmech.2023.115694).
12. Vaishnani M.J., Bijani S., Rahamathulla M., Baldaniya L., Jain V., Thajudeen K.Y., Ahmed M.M., Farhana S.A., and Pasha I. (2024) Biological Importance and Synthesis of 1,2,3-Triazole Derivatives: a review. Green Chem. Lett. and Rev., 17 (1) (https://doi.org/10.1080/17518253.2024.2307989).
13. Marzi M., Farjam M., Kazeminejad Z., Shiroudi A., Kouhpayeh A., Zarenezhad E. (2022) A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR). J. Chem., 1 7884316 (https://doi.org/10.1155/2022/7884316).
14. Singh A., Singh K., Sharma A., Joshi K., Singh B., Sharma S., Batra K., Kaur K., Singh D., Chadha R., Mohinder P., Bedi S. (2023) 1,2,3-Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review. Chem. Biodiversity., 20 (5) e202300024 (https://doi.org/10.1002/cbdv.202300024).
15. Hrimla M., Bahsis L., Laamari M.R., Julve M., and Stiriba S.-E. (2022) An Overview on the Performance of 1,2,3-Triazole Derivatives as Corrosion Inhibitors for Metal Surfaces. Int. J. Mol. Sci., 23 (1) 16 (https://doi.org/10.3390/ijms23010016).
16. Farooq T. (2021) Triazoles in Material Sciences. Advances in Triazole Chemistry, 223-244 (https://doi.org/10.1016/B978-0-12-817113-4.00002-0).
17. Marinova P., and Hristov M. (2023) Synthesis and Biological Activity of Novel Complexes with Anthranilic Acid and its Analogues. Appl. Sci., 13 9426 (https://doi.org/10.3390/app13169426).
18. Jaramillo A.V.C., Cory M.B., Li A., Kohli R.M., and Wuest W.M. (2022) Exploration of Inhibitors of the Bacterial LexA Repressor-protease. Bioorg. Med. Chem. Lett., 65 128702 (https://doi.org/10.1016/j.bmcl.2022.128702).
19. Kiselyov A., Semenova M., and Semenov V.V. (2009) (1,2,3-Triazol-4-yl)benzenamines: Synthesis and Activity Against VEGF receptors 1 and 2. Bioorg. Med. Chem. Lett., 19 (5) 1344-1348 (https://doi.org/10.1016/j.bmcl.2009.01.046).
20. Lan J., Cadassou O., Corbet C., Riant O., and Feron O. (2022) Discovery of Mitochondrial Complex I Inhibitors as Anticancer and Radiosensitizer Drugs Based on Compensatory Stimulation of Lactate Release. Cancers., 14 (21) 5454 (https://doi.org/10.3390/cancers14215454).
21. Mu R., Zhou Y., Chen L., Wei H., Yu J., Gou W., Ye C., Hou W., Li Y., and Zhu L. (2021) Discovery of Novel Triazole Compounds as Selective IL-1β Releasement Inhibitors. Bioorg. Med. Chem. Lett., 53 128415 (https://doi.org/10.1016/j.bmcl.2021.128415).
22. Pokhodylo N., Manko N., Finiuk N., Klyuchivska O., Matiychuk V., Obushak M., and Stoiko R. (2021) Primary Discovery of 1-Aryl-5-substituted-1H-1,2,3-triazole-4-carboxamides as Promising Antimicrobial Agents. J. Mol. Struct., 1246 131146 (https://doi.org/10.1016/j.molstruc.2021.131146).
23. Selwood T., Larsen B.J., Mo C.Y., Culyba M.J., Hostetler Z.M., Kohli R.M., Reitz A.B., and Baugh S.D.P. (2018) Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response. Front. Microbiol. 9 2961 (https://doi.org/10.3389/fmicb.2018.02961).
24. Yuan W., Chen X., Liu N., Wen Y., Yang B., Andrei G., Snoeck R., Xiang Y., Wu Y., Jiang Z., Schols D., Zhang Z., and Wu Q. (2019) Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles. Medicinal Chemistry., 15 (7) 801-812 (https://doi.org/10.2174/1573406414666181109095239).
25. Brand S., Ko E.J., Viayna E., Thompson S., Spinks D., Thomas M., Sandberg L., Francisco A.F., Jayawardhana S., Smith V.C., Jansen C., De Rycker M., Thomas J., MacLean L., Osuna-Cabello M., Riley J., Scullion P., Stojanovski L., Simeons F.R.C., Epemolu O., Shishikura Y., Crouch S.D., Bakshi T.S., Nixon C.J., Reid I.H., Hill A.P., Underwood T.Z., Hindley S.J., Robinson S.A., Kelly J.M., Fiandor J.M., Wyatt P.G., Marco M., Miles T.J., Read K.D., and Gilbert I.H. (2017) Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. J Med Chem., 14 60 (17) 7284-7299 (https://doi.org/10.1021/acs.jmedchem.7b00463).
26. Usachev B.I. (2018) Chemistry of Fluoroalkyl-substituted 1,2,3-Triazoles. J. Fluor. Chem., 210 6-45 (https://doi.org/10.1016/j.jfluchem.2018.02.012).
27. Ullah I., Ilyas M., Omer M., Alamzeb M., Adnan, and Sohail M. (2022) Fluorinated Triazoles as Privileged Potential Candidates in drug Development—focusing on their Biological and Pharmaceutical Properties. Front. Chem., 10 926723 (https://doi.org/10.3389/fchem.2022.926723).
28. Ma J-A., and Cahard D. (2004) Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions. Chem. Rev., 104 6119-6146 (https://doi.org/10.1021/cr030143e).
29. Kaiho T. (2015) Iodine Chemistry and Applications, Wiley-VCH, Weinheim.
30. Ma X., and Song Q. (2020) Recent Progress on Selective Deconstructive Modes of Halodifluoromethyl and Trifluoromethyl-containing Reagents. Chem. Soc. Rev., 49 9197-9219 (https://doi.org/10.1039/D0CS00604A).
31. Wang X., Lei J., Liu Y., Ye Y., Li J., and Sun K. (2021) Fluorination and Fluoroalkylation of Alkenes/Alkynes to Construct Fluorocontaining Heterocycles. Org. Chem. Front., 8 2079-2109 (https://doi.org/10.1039/D0QO01629B).
32. Pokorny J. (2007) Are Natural Antioxidants Better – and Safer – Than Synthetic Antioxidants? Eur. J. Lipid. Sci. Technol., 109 (6) 629-642 (http://dx.doi.org/10.1002/ejlt.200700064).
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