How to cite this paper
Soni, G., Sharma, S & Dangi, N. (2023). In silico molecular docking study and Protective effect of Piper attenuatum on aspirin induced gastric ulcer in rats.Current Chemistry Letters, 12(4), 705-720.
Refrences
1. Gabri NA., Elnagar GM., Saghir SAM., Shaibany AE., Alnomasy SF., Althafar ZM., Elkomy NMIM., Elaasser MM., Abdoh MS., and Yosri M. (2022) Preliminary study of gastroprotective effect of Aloe perryi and date palm extract on pyloric ligation gastric ulcer in experimental rats. Biomed Res. Int., 1-10. https://doi.org/10.1155/2022/9246785
2. Albarri O., Alzeini KWK., Var I., Boushihassal A., Meral M., Onlen C., Bedir B., Kizilyidirim S., Karsli F., and Koksal F. (2018) Antiulcer activity of some selected plants: A review. Int. J. Food Sci. Technol., 6(2), 18-32.
3. Rad MS., Fokou PVT., Sharopov F., Martorell M., Ademiluyi AO., Rajkovic J., Salehi B., Martin N., Iriti M., and Rad JS. (2018) Antiulcer agent: From plant extract to phytochemical in healing promotion. Molecules, 23 (7): 1-37. https://doi.org/10.3390/molecules23071751
4. Tripathi A., Singh S., and Mukerjee A. (2021) Antiulcer activity of ethanolic leaf extract of Capparis zeylanica against chemically induced ulcers. Future J. Pharm. Sci., 7 (211), 1-13.
5. Asnaashari S., Dastmalchi S., and Javadzadeh Y. (2018) Gastroprotective effect of herbal medicines (root). Int. J. Food Prop., 21(1), 902-920. https://doi.org/10.1080/10942912.2018.1473876
6. Menshawy MM., Raey MAI., Hamdy AHA., and Fararg ARH. (2017) Antiulcer activity of Terminalia Loxiflora engl. and Diels leaves extracts against aspirin induced gastric ulcer in rats. Int. J. Adv. Res., 5(7), 2092-2100. http://dx.doi.org/10.21474/IJAR01/4946
7. Noman M., Qazi NG., Rehman NU., and Khan AU. (2022) Pharmacological investigation of brucine antiulcer potential. Front. Pharmacol., 13 1-15. https://doi.org/10.3389/fphar.2022.886433
8. Sahoo SK., Sahoo HB., Priyadarshini D., Soundarya G., Kumar K., and Rani U. (2016) Antiulcer activity of ethanolic extract of Salvadora Indica (W.) leaves on albino rats. J. Clin. Diagnostic Res., 10(9), FF07-FF10.
9. Andargie Y., Sisay W., Molla M., Norahun A., and Singh P. (2022) Evaluation of antiulcer activity of methanolic extract and solvent fractions of leaves of Calpurnia aurea (Ait.) Benth. (Fabaceae) in rats. Evid. Based Complementary Altern. Med., 1-12.
10. Pathak N., and Kumar R. (2019) Piper attenuatum Buch. Ham. ex Miq.- A review on its microscopic characters., phytochemistry., medicinal importance and its comparative study with other piper species. Curr. Med. Drug. Res., 3(2), 1-10.
11. Soni G. and Govindasamy J. (2021) Hepatoprotective potential of ethanolic leaf extract of plant Piper attenuatum B. Ham. and Caesalpinia crista linn. Int. J. Drug Dev. Res., 13(3), 1-5.
12. Kim YJ., Deok J., Kim S., Yoon DH., Sung GH., and Aravinthan A. (2017) Anti-Inflammatory effect of Piper attenuatum methanol extract in LPS – stimulated inflammatory response. Evid Based Complement. Alternat. Med., 1-10.
13. Soni G., Govindasamy J., and Ahuja A. (2021) Antioxidant and skeletal muscle relaxant activity of leaf extract of Piper attenuatum B. Ham. Indian J. Pharm. Biol. Res., 9(1), 8-15.
14. Soni GK., and Verma T. (2013) Antihyperlipidemic activity of seed extract of Piper attenuatum in triton –X 100 induced hyperlipidemia in rats. J. Chem. Pharm. Res., 5(12), 1370-1373.
15. Ohlyan R., Kandale A., Deora GS., Rathore V., and Chahal J. (2013) Invitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity. Med. Chem. Res., 22, 1365-1370.
16. Salehi B., Zakaria ZA., Gyawali R., Ibrahim SA., Rajkovic J., and Shinwari ZK. (2019) Piper species: A comprehensive review on their phytochemistry biological activities and application. Molecules, 24, 1-118.
17. Chandra S., and Meel RK. (2014) A systematic comparative study of Morinda tinctoria and Vitex Negundo for their antiulcerogenic activity. World J. Environ. Biosci., 11(1), 45-52.
18. Ahmed O., Nedi T., and Yimer EM. (2022) Evaluation of anti-gastric ulcer activity of aqueous and 80 % methanol leaf extracts of Urtica simenesis in rats. Metabolism open, 14, 1-7.
19. Kokate CK., Purohit AP., and Gokhale SB. Pharmacognosy. (2004) 24th ed. Pune: Nirali Prakashan; 2003.
20. Evans WC. Pharmacognosy. 15th ed. New York: Oxford Philadelphia; 2000.
21. Sahu VK., Irchhaiya R., Sashi A., and Gurjar H. (2010) Phytochemical investigation and chromatographic evaluation of ethanolic extract of whole plant extract of Dendrophthoe falcata (l.f.) Ettingsh. Int. J. Pharm. Sci. Res., 1(1), 39-45.
22. Valle DL., Puzon JJM., Cabrera EC., and Rivera WL. (2016) Thin layer chromatography Bioautography & Gas chromatography - Mass Spectrometry of antimicrobial leaf extract from Philippines Piper betel L. against multidrug resistant Bacteria. Evid-Based Complement. Altern. Med., 1-7.
23. Patel N., and Mohan JSS. (2017) Isolation and characterization of potential bioactive compounds from Piper betle varieties Banarasi and Bengali leaf extract. Int. J. Herb. Med., 5(5), 182 - 191.
24. Kumar CP., Prathap P., Kazmi MH., and Darshanala A. (2019) Evaluation of antiulcer activity by using flower extract of Ctenolepis garcini in aspirin induced rats. Int. J. Res. Rev., 6(11), 209-213.
25. Hammed MA., Adedotun IO., Victoria AF., Adewusi J., Adepoju SB., and Olasupo MW. (2021). Target-Based Drug Discovery, ADMET Profiling and Bioactivity Studies of Antibiotics as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro), Research square, https://www.researchsquare.com/article/rs-310136/ latest.pdf.
26. Lipinski CA. (2004) Lead- and drug-like compounds: The rule-of-five revolution, Drug Discov. Today Technol., 1(4), 337–341, https://doi.org/10.1016/j. ddtec.2004.11.007.
27. Giacomini KM., Huang SM., Tweedie DJ., Benet LZ., Brouwer KL., Chu X., Dahlin A., Evers R., Fischer V., Hillgren KM., Hoffmaster KA., Ishikawa T., Keppler D., Kim RB., Lee CA., Niemi M., Polli JM., Sugiyama Y., Swaan PW., and Zhang L. (2010) Membrane transporters in drug development, Nat. Rev. Drug Discov., 9 (3), 215–236, https://doi.org/10.1038/nrd3028.
28. Veber DF., Johnson SR., Cheng HY., Smith BR., Ward KW., and Kopple KD. (2002) Molecular Properties That Influence the Oral Bioavailability of Drug Candidates, J. Med. Chem., 45 (12) 2615–2623, https://doi.org/10.1021/jm020017n
29. Abe K., Tani K., and Fujiyoshi Y (2011) Conformational rearrangement of gastric H+/K+-ATPase induced by an acid suppressant. Nat. Commun., 2, 155
30. Beil W., Hackbarth I., and Sewing KF (1986) Mechanism of gastric antisecretory effect of SCH 28080. Br. J. Pharmacol., 88, 19–23
31. Trott O. , and Olson AJ (2009) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem., 31 (2), 455–461, https://doi.org/10.1002/jcc.21334.
32. Dallakyan S., and Olson AJ. (2015) Small-Molecule Library Screening by Docking with PyRx, Chem. Bio., 1263. https://link.springer.com/protocol/10.1007/978-1-49 39-2269-7_19
33. Shim YK., and Kim N. (2016) Non-steroidal anti-inflammatory drugs and aspirin induced peptic ulcer disease. Korean J. Gastroenterol., 67(6), 300-312.
34. Sabina EP., Nasreen A., Vedi M., and Rasool M. (2013) Analgesic, antipyretic and ulcerogenic effect of Piperine: An active ingredient of Pepper. J. Pharm. Sci. Res., 5(10), 203-206.
35. Faassen F, Vogel G, Spanings H, and Vromans H. (2003) Caco-2 permeability, P glycoprotein transport ratios and brain penetration of heterocyclic drugs, Int. J. Pharm., 263 113–122, https://doi.org/10.1016/S0378-5173(03)00372-7.
36. Roberts JA, Pea F, and Lipman J. (2013) The Clinical Relevance of Plasma Protein Binding Changes, Clin. Pharmacokin., 52(1), 1–8, https://doi.org/ 10.1007/s40262-012-0018-5
2. Albarri O., Alzeini KWK., Var I., Boushihassal A., Meral M., Onlen C., Bedir B., Kizilyidirim S., Karsli F., and Koksal F. (2018) Antiulcer activity of some selected plants: A review. Int. J. Food Sci. Technol., 6(2), 18-32.
3. Rad MS., Fokou PVT., Sharopov F., Martorell M., Ademiluyi AO., Rajkovic J., Salehi B., Martin N., Iriti M., and Rad JS. (2018) Antiulcer agent: From plant extract to phytochemical in healing promotion. Molecules, 23 (7): 1-37. https://doi.org/10.3390/molecules23071751
4. Tripathi A., Singh S., and Mukerjee A. (2021) Antiulcer activity of ethanolic leaf extract of Capparis zeylanica against chemically induced ulcers. Future J. Pharm. Sci., 7 (211), 1-13.
5. Asnaashari S., Dastmalchi S., and Javadzadeh Y. (2018) Gastroprotective effect of herbal medicines (root). Int. J. Food Prop., 21(1), 902-920. https://doi.org/10.1080/10942912.2018.1473876
6. Menshawy MM., Raey MAI., Hamdy AHA., and Fararg ARH. (2017) Antiulcer activity of Terminalia Loxiflora engl. and Diels leaves extracts against aspirin induced gastric ulcer in rats. Int. J. Adv. Res., 5(7), 2092-2100. http://dx.doi.org/10.21474/IJAR01/4946
7. Noman M., Qazi NG., Rehman NU., and Khan AU. (2022) Pharmacological investigation of brucine antiulcer potential. Front. Pharmacol., 13 1-15. https://doi.org/10.3389/fphar.2022.886433
8. Sahoo SK., Sahoo HB., Priyadarshini D., Soundarya G., Kumar K., and Rani U. (2016) Antiulcer activity of ethanolic extract of Salvadora Indica (W.) leaves on albino rats. J. Clin. Diagnostic Res., 10(9), FF07-FF10.
9. Andargie Y., Sisay W., Molla M., Norahun A., and Singh P. (2022) Evaluation of antiulcer activity of methanolic extract and solvent fractions of leaves of Calpurnia aurea (Ait.) Benth. (Fabaceae) in rats. Evid. Based Complementary Altern. Med., 1-12.
10. Pathak N., and Kumar R. (2019) Piper attenuatum Buch. Ham. ex Miq.- A review on its microscopic characters., phytochemistry., medicinal importance and its comparative study with other piper species. Curr. Med. Drug. Res., 3(2), 1-10.
11. Soni G. and Govindasamy J. (2021) Hepatoprotective potential of ethanolic leaf extract of plant Piper attenuatum B. Ham. and Caesalpinia crista linn. Int. J. Drug Dev. Res., 13(3), 1-5.
12. Kim YJ., Deok J., Kim S., Yoon DH., Sung GH., and Aravinthan A. (2017) Anti-Inflammatory effect of Piper attenuatum methanol extract in LPS – stimulated inflammatory response. Evid Based Complement. Alternat. Med., 1-10.
13. Soni G., Govindasamy J., and Ahuja A. (2021) Antioxidant and skeletal muscle relaxant activity of leaf extract of Piper attenuatum B. Ham. Indian J. Pharm. Biol. Res., 9(1), 8-15.
14. Soni GK., and Verma T. (2013) Antihyperlipidemic activity of seed extract of Piper attenuatum in triton –X 100 induced hyperlipidemia in rats. J. Chem. Pharm. Res., 5(12), 1370-1373.
15. Ohlyan R., Kandale A., Deora GS., Rathore V., and Chahal J. (2013) Invitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity. Med. Chem. Res., 22, 1365-1370.
16. Salehi B., Zakaria ZA., Gyawali R., Ibrahim SA., Rajkovic J., and Shinwari ZK. (2019) Piper species: A comprehensive review on their phytochemistry biological activities and application. Molecules, 24, 1-118.
17. Chandra S., and Meel RK. (2014) A systematic comparative study of Morinda tinctoria and Vitex Negundo for their antiulcerogenic activity. World J. Environ. Biosci., 11(1), 45-52.
18. Ahmed O., Nedi T., and Yimer EM. (2022) Evaluation of anti-gastric ulcer activity of aqueous and 80 % methanol leaf extracts of Urtica simenesis in rats. Metabolism open, 14, 1-7.
19. Kokate CK., Purohit AP., and Gokhale SB. Pharmacognosy. (2004) 24th ed. Pune: Nirali Prakashan; 2003.
20. Evans WC. Pharmacognosy. 15th ed. New York: Oxford Philadelphia; 2000.
21. Sahu VK., Irchhaiya R., Sashi A., and Gurjar H. (2010) Phytochemical investigation and chromatographic evaluation of ethanolic extract of whole plant extract of Dendrophthoe falcata (l.f.) Ettingsh. Int. J. Pharm. Sci. Res., 1(1), 39-45.
22. Valle DL., Puzon JJM., Cabrera EC., and Rivera WL. (2016) Thin layer chromatography Bioautography & Gas chromatography - Mass Spectrometry of antimicrobial leaf extract from Philippines Piper betel L. against multidrug resistant Bacteria. Evid-Based Complement. Altern. Med., 1-7.
23. Patel N., and Mohan JSS. (2017) Isolation and characterization of potential bioactive compounds from Piper betle varieties Banarasi and Bengali leaf extract. Int. J. Herb. Med., 5(5), 182 - 191.
24. Kumar CP., Prathap P., Kazmi MH., and Darshanala A. (2019) Evaluation of antiulcer activity by using flower extract of Ctenolepis garcini in aspirin induced rats. Int. J. Res. Rev., 6(11), 209-213.
25. Hammed MA., Adedotun IO., Victoria AF., Adewusi J., Adepoju SB., and Olasupo MW. (2021). Target-Based Drug Discovery, ADMET Profiling and Bioactivity Studies of Antibiotics as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro), Research square, https://www.researchsquare.com/article/rs-310136/ latest.pdf.
26. Lipinski CA. (2004) Lead- and drug-like compounds: The rule-of-five revolution, Drug Discov. Today Technol., 1(4), 337–341, https://doi.org/10.1016/j. ddtec.2004.11.007.
27. Giacomini KM., Huang SM., Tweedie DJ., Benet LZ., Brouwer KL., Chu X., Dahlin A., Evers R., Fischer V., Hillgren KM., Hoffmaster KA., Ishikawa T., Keppler D., Kim RB., Lee CA., Niemi M., Polli JM., Sugiyama Y., Swaan PW., and Zhang L. (2010) Membrane transporters in drug development, Nat. Rev. Drug Discov., 9 (3), 215–236, https://doi.org/10.1038/nrd3028.
28. Veber DF., Johnson SR., Cheng HY., Smith BR., Ward KW., and Kopple KD. (2002) Molecular Properties That Influence the Oral Bioavailability of Drug Candidates, J. Med. Chem., 45 (12) 2615–2623, https://doi.org/10.1021/jm020017n
29. Abe K., Tani K., and Fujiyoshi Y (2011) Conformational rearrangement of gastric H+/K+-ATPase induced by an acid suppressant. Nat. Commun., 2, 155
30. Beil W., Hackbarth I., and Sewing KF (1986) Mechanism of gastric antisecretory effect of SCH 28080. Br. J. Pharmacol., 88, 19–23
31. Trott O. , and Olson AJ (2009) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem., 31 (2), 455–461, https://doi.org/10.1002/jcc.21334.
32. Dallakyan S., and Olson AJ. (2015) Small-Molecule Library Screening by Docking with PyRx, Chem. Bio., 1263. https://link.springer.com/protocol/10.1007/978-1-49 39-2269-7_19
33. Shim YK., and Kim N. (2016) Non-steroidal anti-inflammatory drugs and aspirin induced peptic ulcer disease. Korean J. Gastroenterol., 67(6), 300-312.
34. Sabina EP., Nasreen A., Vedi M., and Rasool M. (2013) Analgesic, antipyretic and ulcerogenic effect of Piperine: An active ingredient of Pepper. J. Pharm. Sci. Res., 5(10), 203-206.
35. Faassen F, Vogel G, Spanings H, and Vromans H. (2003) Caco-2 permeability, P glycoprotein transport ratios and brain penetration of heterocyclic drugs, Int. J. Pharm., 263 113–122, https://doi.org/10.1016/S0378-5173(03)00372-7.
36. Roberts JA, Pea F, and Lipman J. (2013) The Clinical Relevance of Plasma Protein Binding Changes, Clin. Pharmacokin., 52(1), 1–8, https://doi.org/ 10.1007/s40262-012-0018-5