Many startups fail, and we still do not know why. It is the purpose of this study to know if a relationship exists between business model innovation and startup, and whether networking and competitive advantage can improve their relationship. We hypothesized that business model innovation relates to startup and that networking and competitive advantage significantly enhance the relationship between business model innovation and startup. Fifty-one respondents participate in this study. The partial least square statistical technique is used to analyze the data. This analytical technique is appropriate for parametric analysis for such a sample size. The null hypothesis that no relationship exists between business model innovation and startup is rejected. The null hypothesis that networking and competitive advantage is not related to business model innovation is also rejected. However, the null hypothesis that there is no direct relationship between networking and startup is accepted; the association is not direct but indirect. The null hypothesis that no direct association between competitive advantage and startup is rejected. There is a negative association between competitive ad-vantage and startup. Both networking and competitive advantage improve the relationship between business model innovation and startup. However, they must be used with caution.