Current study aims to examine the relationship between knowledge management and performance excellence through the effect of knowledge management (KM) on technological vigilance within pharmaceutical manufacturing organizations in Jordan. Depending on quantitative approach, 270 questionnaires were distributed among employees and leaders of 49 pharmaceutical manufacturing organizations in Jordan to examine the effect of KM and its chosen variables, Organizational Culture, Leadership, Organizational Processes, Organization's Politics and Strategies, on delivering organization to performance excellence through the mediating role of technological vigilance. Results of the study indicate a positive influence of KM on delivering organization to excellence; this influence was attributed to mainly leadership as the basic driver. The results also indicate that technological vigilance mediates the relationship between knowledge management and delivering the organization to the state of performance excellence. Moreover, the study results indicate that KM enhances the organization's ability to retain and improve organizational performance and helps deliver it to excellence based on experience and knowledge. Knowledge management allows the institution to define the required knowledge, document, develop, share, apply and evaluate this knowledge and it is an approach for excellent performance. Study recommends increasing efforts towards providing the requirements of applying knowledge management, and the need for organizational structures to be horizontal and flexible, and there must be conscious and eager leadership to apply knowledge management and encourage the exchange of information, and the need for organizational culture to be conducive to the application of knowledge.