Due to its proactive impact on the serviceability of components in a system, preventive maintenance plays an important role particularly in systems of geographically spread infrastructure such as utilities networks in commercial buildings. What makes such systems differ from the classical schemes is the routing and technicians' travel times. Besides, maintenance in commercial buildings is characterized by its short tasks’ durations and spatial distribution within and between different buildings, a class of problems that has not been suitably investigated. Although it is not trivial to assign particular duties solely to multi-skilled teams under limited time and capacity constraints, the problem becomes more challenging when travel routes, durations and service levels are considered during the execution of the daily maintenance tasks. To address this problem, we propose a Mixed Integer Linear Programming Model that considers the above settings. The model exact solution recommends collaborative choices that include the number of maintenance teams, the selected tasks, routes, tasks schedules, all detailed to days and teams. The model will reduce the cost of labor, replacement parts, penalties on service levels and travel time. The optimization model has been tested using different maintenance scenarios taken from a real maintenance provider in the UAE. Using CPLEX solver, the findings demonstrate an inspiring time utilization, schedules of minimal routing and high service levels using a minimum number of teams. Different travel speeds of diverse assortment of tasks, durations and cost settings have been tested for further sensitivity analysis.

This study examines the interaction effect between transformational leadership, transactional leadership, wireless IT competence, ambidexterity and supply chain management capability in increasing innovation capability. By using a knowledge-based view and dynamic capability theory basis, this research has provided an exploration of the supply chain of a merchant marine college and its impact on innovation capability using a quantitative method approach. The authors collected data from a cross-section of 673 questionnaires distributed to Managers in 3 managerial classifications from top, middle and bottom in the technical service unit of the merchant marine college under the Indonesian Ministry of Transportation. A total of 523 data were collected from questionnaires that could be continued for data analysis. The results of this study indicate that all the hypotheses put forward in this study are accepted, and the role of mediating variables in this research has succeeded in demonstrating their role in mediating each antecedent variable to increase innovation capability. The theoretical implication of this research is the growth of cloud or virtual supply chains facilitated by digital wireless communications, and internet technology is advancing logistics and supply chain innovations. Also, it can reinforce theory and dynamic capability.

The permanence and durability of mechanical and structural elements with discontinuities such as cracks and voids require the calculation of SIF (stress intensity factors) with reasonable fidelity. SIF is a crucial parameter that predicts crack growth and failure behavior by quantifying the stress field neighboring the crack tip. Therefore, understanding the sophisticated characteristics of the stress fields in the vicinity of discontinuity requires an effective way of calculating SIFs. Currently, there are numerous methods to calculate SIF, such as FVM (Finite Volume Method), FEM (Finite Element Method), BEM (Boundary Element Method), XFEM (Extended Finite Element Method), Phase field method and Meshfree methods. For an extended period, FEM is one of the leading methods in solving fracture mechanics problems. Though FEM is quite robust in dealing with several engineering problems, it has got its inherent drawbacks to deal with singular fields like discontinuities. Hence to reasonably capture moving discontinuities, finer meshes near the discontinuous field are required that demand more computation effort and time. To alleviate the above drawback of FEM, this study employed Extended Isogeometric Analysis (XIGA) to efficiently and effectively determine the SIFs in the case of fissured plates as benchmarking fissure problems. In this study SIFs in relation to crack length were examined for edge and center cracked plates and results were compared with the theoretical values.

Pyrazolones are a class of heterocyclic compounds that contain a pyrazole ring fused to a ketone group. Recent scientific research has focused extensively on the potential anti-inflammatory properties of pyrazolone compounds due to their diverse pharmacological effects in alleviating inflammation and reducing fever. This motivated us to focus on the preparation of these derivatives in a simple and eco-friendly manner. A convenient new green methodology was modified for the preparation of 1-phenyl-3,5-pyrazolidinedione by the sonicated MCR of diethyl malonate, phenylhydrazine, and a catalytic amount imidazole as homogenous organic catalyst in water green solvent in a good yield. On the other hand, some of 4-arylidinepyrazolidinedione derivatives are prepared in the same manner via the treatment of a mixture of diethyl malonate, phenylhydrazine, aromatic aldehydes, and a catalytic amount of imidazole in an aqueous medium. Our target synthesized pyrazolidinediones were elucidated via elemental and several spectral analyses. Due to the importance of pyrazolidinediones in the field of treating inflammation and relieving pain, a number of prepared compounds were chosen to test their efficacy as anti-inflammatory agents using carrageenan-induced foot edema in rats and compare the results with indomethacin, the standard drug. We found that the majority of derivatives yield promising results spanning from good to wonderful, so derivatives (15k, 15b, 15h, 15a, and 15j) yield the best results while derivative (15i) yields an average result. As for the derivative (15f), it yields the lowest results compared to the standard drug. This is due to the difference in the structural composition of these derivatives, which increases the likelihood of their use as anti-inflammatory derivatives.

The socio-economic development of each country requires the contribution of businesses to social goals and the state budget. Improving tax compliance behavior is consistent with improving the ability of businesses to contribute to the budget. The objective of the study is to evaluate factors affecting tax compliance behavior for businesses. The study is conducted on 202 enterprises in Thai Nguyen, a locality located in the key economic region of Vietnam and with a high level of economic development. Through quantitative analysis of the research results, it found that: the system legislation and socio-economic conditions have the strongest influence on businesses' tax compliance behavior. However, the influence of business characteristics and tax authority characteristics on tax compliance behavior is lower.

The Refrigerated Capacitated Vehicle Routing Problem (RCVRP) considers a homogeneous fleet with a refrigerated system to decide the selection of routes to be performed according to customers' requirements. The aim is to keep the energy consumption of the routes as low as possible. We use a thermodynamic model to understand the unloading of products from trucks and the variables' efficiency, such as the temperature during the day influencing energy consumption. By considering various neighborhoods and a shaking procedure, this paper proposes a Granular Tabu Search scheme to solve the RCVRP. Computational tests using adapted benchmark instances from the literature demonstrate that the suggested method delivers high-quality solutions within short computing times, illustrating the refrigeration system's effect on routing decisions.

This study examines the impact of relaxation of Foreign Direct Investment (FDI) access on the trans-regional investment behavior of Indonesian enterprises. Utilizing data from publicly listed companies between 2010 and 2022, this study investigates how easing FDI restrictions influences the geographic distribution of subsidiaries. The findings indicate that FDI access relaxation significantly promotes trans-regional investment, driven by reduced government subsidies and lower market intervention. These mechanisms enable enterprises to expand beyond local markets by decreasing their dependency on government support and lowering their transaction costs. Robustness tests, including first-order difference models and dynamic distribution tests, confirmed the reliability of the results. This study suggests that a further reduction in FDI restrictions can enhance domestic market integration, mitigate capital market segmentation, and promote inclusive economic growth. This study contributes to the literature by providing empirical evidence of the economic benefits of FDI access policies and offers new strategies for addressing market segmentation in Indonesia.

The effect of pH value at three levels (5, 7, and 9) and temperature at two levels (25 and 50ºC) on the sorption properties of chlorantraniliprole-CAP, dinotefuran-DNF, bispyribac-sodium-BPS, and metribuzin-MBZ were studied in calcareous soil. The sorption of CAP at pH 5 (38.2%) was significantly higher than that at pH 7 (32.4%) and 9 (28.4%), whereas the sorption of DNF at pH 5 was lower than that at pH 7. The adsorption of BPS at pH 9 was statistically significantly higher than that at pH 5 and pH 7. Regarding the herbicide MBZ adsorption percentages were 47.0, 61.1 and 57.1 % at pH 5, 7 and 9. The number of tested pesticides adsorbed by the soil was significantly influenced by the temperature. The adsorbed amount of CAP was decreased from 37% to 33% as the temperature was increased from 25˚C to 50 ˚C, while no significant differences of adsorbed DNF. Data showed that the adsorption of BPS and MBZ statistically decreases with temperature. The data from the adsorption behaviour of CAP, DNF, BPS, and MBZ in tested soil at different temperatures correspond well with the Freundlich isotherm. The negative ΔG˚ indicated that the adsorption of CAP, DNF, BPS, and MBZ were spontaneous at different temperatures. There was an increase in the entropy of the pesticide-soil systems as shown by the positive values of ΔS˚.

There were still contradictory results from earlier research on the relationship between organizational innovation, performance, and management control systems (MCS). In order to account for these contradictory results, future studies ought to concentrate on the empirical analysis of Simon's MCS theory. The purpose of the study was to assess the mediation and moderation model in relation to performance, innovation, and MCS. The study intends to broaden the scope by employing a more thorough definition and measurement of research variables. Because the Partial Least Square (PLS) can concurrently assess the existence of a dual dependency relationship of a latent variable, the study used PLS to test the hypothesis. The mediated hypothesis which holds that MCS indirectly affects performance through innovation seems to be supported by these data. All things considered, this study contributes to the understanding of the ambiguous and contradictory conclusions of earlier studies that examined the connection between MCS, innovation, and performance.

A crucial direction in the progress of modern medical chemistry is the development and improvement of theoretical investigation methods of drugs mechanisms of action, predicting their activity, and virtual design of new drugs. This review describes the history of targeted search for biologically active compounds, current in silico approaches and tools used in the rational design of potential drugs, in particular the main computational strategies used in modern drug design are presented and outlines the main methodologies for implementing these strategies.