In our present investigation a new series of nucleoside derivatives (2-13) were synthesized from uridine (1) via only two step reactions by direct acylation method. Firstly, uridine (1) was treated with 4-t-butylbenzoyl chloride in pyridine at -5?C and afforded the 5´-O-(4-t-butylbenzoyl)uridine derivative (2) in an excellent yield. In order to obtain newer products, the 5´-O-uridine derivative was further transformed to a series of 2´,3´-di-O-acyl derivatives (2-13) containing a wide variety of functionalities in a single molecular framework. The yields of the compounds were more than 80%. The synthesized titled compounds were characterized by their physical properties, FTIR (Fourier transform infrared spectroscopy), 1H-NMR (Nuclear magnetic resonance) spectroscopy and elemental analysis.
The present work summarizes some recent experimental, theoretical and numerical results on brittle fracture of isostatic polycrystalline graphite. The analyses have been carried out on V-notched samples under mixed mode (I+II), torsion and compression loading, considering various combinations of the notch tip radius, opening angle and notch tilt angle. The static strength of the considered specimens is assessed through an approach based on the strain energy density averaged over a control volume. The center of the control volume is located on the notch edge, where the principal stress reaches its maximum value. The correct orientation is obtained by a rigid rotation of the crescent-shaped volume while the size depends on the fracture toughness and the ultimate strength of the material. This methodology has been already used in the literature to analyze U- and V-shaped notches subject to mode I loading with very good results and advantages with respect to classic approaches. The results reported in this new work show, also under mixed mode loading conditions, good agreement between experimental data and theoretical predictions.
This paper describes a harmless HPLC technique for detecting imidacloprid (ICP) and its metabolite, 6-chloronicotinic acid (6CA), using an isocratic 100 % water mobile phase. Chromatographic separations were performed a Daisopak® SP-200-3-C1-P with water mobile phase and a photodiode-array detector. The total run time was & LT; 6 min. The system suitability was well within the international acceptance criteria. The detection limits were 0.018 ?g/ml for ICP and 0.005 ?g/ml for 6CA, respectively. A harmless HPLC method for simultaneous detecting ICP and 6CA was developed and may be further applied to the quantification in animal-derived foods.
One of the specimens to investigate the mode-I fracture toughness of rock and geo-materials is semi-circular bend (SCB) specimen. In general, initial cracks in rock test specimens are produced in two shapes: straight-edge cracks and chevron notches. The ISRM suggested SCB specimen has straight shaped notch. However, use of V-shaped (or chevron) notch in the SCB specimen is preferred because of some technical difficulties associated with making a sharp crack or creating pre-crack to conduct the experimental tests. In this paper, the minimum dimensionless stress intensity factor of cracked chevron notched semi-circular bend (CCNSCB) specimen is determined using finite element analysis with ABAQUS software. An analytical method, (i.e. Bluhm’s slice synthesis method) is used to verify the results. It is shown that a good agreement exists between the numerical data and theoretical results.
The classical production-inventory model assumes that both demand and set-up costs are constant. However, in real manufacturing environment, managers usually embark on continuous improvement programmes that often lead to more effective use of tools and machineries and consequently reduction in set-up costs. In fact, constant emphasis on reduction of set-up costs is usually cited as one of the factors responsible for the efficiency of Japanese manufacturing methods. On the other hand, the demand for seasonal product is often characterized by a mixture of time-dependent patterns over the entire season. This paper investigates the effect of learning-based reduction in set-up costs on the optimal schedules and costs of a production-inventory system for deteriorating seasonal products. The demand pattern is a general three-phase ramp-type demand function that represents the various phases of demand commonly observed in many seasonal products in the market. A two-parameter Weibull-distribution function is used for the deterioration of items in order to make the model more generalized and realistic. The study further presents two different multi-period production strategies that can ensure a fast-response to customers’ demand and compare them with the usual single period strategy. The Numerical example and sensitivity analysis shows that learning-based reduction in set-up costs leads to higher production frequency and shorter production runs which are vital aspects of the just-in-time (JIT) philosophy.
This paper presents our research works on integrating disassembly sequence planning with cost model for end-of-life (EOL) product. This paper has two objectives. The first objective is to optimize disassembly sequence of the EOL product. We integrate a traveling salesman problem approach with genetic algorithm in finding the optimal disassembly sequence for disassembling the EOL product. Based on this optimal sequence, the second objective is to identify the best EOL option. We employ EOL profits and net present value of parts and subassemblies of the EOL product to determine the best EOL option of components and parts of the EOL product. The predicted results showed that the developed cost model has reached a good correspondence with the established methods.
This paper presents production-inventory models for deteriorating items with increasing-steady-decreasing demand pattern under the effect of inflation and time value of money. This type of demand behavior can be observed in some fashion products or seasonal products in general. Shortages are allowed with partial backlogging of demand and a two-parameter Weibull-distribution function is used for the deterioration of items in order to make the models more generalized and realistic. The models generate optimal values of initial production run time, onset of shortages, production recommencement time, and total production quantity that minimizes the total relevant costs of production and inventory for any given set of system parameters. Various possible production strategies available for items with variable demand pattern are examined to determine the optimal production strategy. The discounted cash flow approach and trust region optimization methods are used to obtain the optimal results. The Numerical examples and sensitivity analysis show that the optimal production strategy may vary with changes in system parameters.
The primary assumptions with many multi-period inventory lot-sizing models are fixed time horizon and uniform demand variation within each period. In some real inventory situations, however, the time horizon may be unknown, uncertain or imprecise in nature and the demand pattern may vary within a given replenishment period. This paper presents an economic order quantity model for deteriorating items where demand has different pattern with unknown time horizon. The model generates optimal replenishment schedules, order quantity and costs using a general ramp-type demand pattern that allows three-phase variation in demand. Shortages are allowed with full backlogging of demand and all possible replenishment scenarios that can be encountered when shortages and demand pattern variation occur in multi-period inventory modeling are also considered. With the aid of numerical illustrations, the advantages of allowing for variation in demand pattern within replenishment periods, whenever they occur, are explored. The numerical examples show that the length of the replenishment period generated by the model varies with the changes in demand patterns.