The present study examines the relationship between high performance human resource (HPHR) system and organizational citizenship behavior (OCB) in Vietnamese enterprises, and explores the mediating role of job satisfaction in this interaction. Data collected from 179 line managers working in Vietnamese companies by structured questionnaires. The results indicate that the positive relationship between HPHR system and organizational citizenship behavior was mediated by job satisfaction. The study also provides an evidence in terms of the application of HPHR system to foster the organizational outcomes and contributes to understand the underlying mechanism in human resource system and employee’s behaviors relationship.