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Growing Science » Current Chemistry Letters » Synthesis of β-amino alcohols by ring opening of epoxides with amines catalyzed by sulfated tin oxide under mild and solvent-free conditions

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 13 Issue 2 pp. 343-350 , 2024

Synthesis of β-amino alcohols by ring opening of epoxides with amines catalyzed by sulfated tin oxide under mild and solvent-free conditions Pages 343-350 Right click to download the paper Download PDF

Authors: Chintalapudi Rama Krishna, K. Aparna Seetharam, T. N. V. S. S. Satyadev

DOI: 10.5267/j.ccl.2023.11.004

Keywords: Ring opening, Epoxides, Sulfated tin oxide (STO), Amines and β-amino alcohols

Abstract: One significant and elegant method for creating β-amino alcohols, which are useful intermediates for the synthesis of many different natural and synthetic pharmaceutical compounds, is to open the rings of epoxides with amines. When sulfated tin oxide catalyst (2 mol%) is present, epoxides can open their rings and react with amines to produce corresponding β-amino alcohols in good to high yields under mild circumstances. Under clean circumstances and in a short amount of time, the reaction demonstrated high regioselectivity and functioned well with both aromatic and aliphatic amines at room temperature.

How to cite this paper
Krishna, C., Seetharam, K & Satyadev, T. (2024). Synthesis of β-amino alcohols by ring opening of epoxides with amines catalyzed by sulfated tin oxide under mild and solvent-free conditions.Current Chemistry Letters, 13(2), 343-350.

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Journal: Current Chemistry Letters | Year: 2024 | Volume: 13 | Issue: 2 | Views: 828 | Reviews: 0

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