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Growing Science » Current Chemistry Letters » Batch and merging-zone flow injection methods for determination of tetracycline hydrochloride

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Current Chemistry Letters

ISSN 1927-730x (Online) - ISSN 1927-7296 (Print)
Quarterly Publication
Volume 12 Issue 4 pp. 677-684 , 2023

Batch and merging-zone flow injection methods for determination of tetracycline hydrochloride Pages 677-684 Right click to download the paper Download PDF

Authors: Esraa Rasool Radhi, Khdeeja Jabbar Ali, Fatima Hydar Abdul Hussein

DOI: 10.5267/j.ccl.2023.6.001

Keywords: Flow Injection System, Batch Methods, Tetracycline Hydrochloride, Determination, Potassium Permanganate

Abstract: The objective of the present work is to develop batch and merging-zone flow injection methods for sensitive and accurate spectrophotometric determination of tetracycline hydrochloride. The methods depend on the oxidation of the studied drug with potassium permanganate in an alkaline medium, and the absorbance of the green oxidation product was measured at 610 nm. The calibration graphs in both procedures were linear in the concentration ranges of 0.5 – 25 and 1 – 25 μg mL−1 using the spectrophotometric and merging-zone flow injection methods, respectively. Specific and molar absorption coefficients, limits of detection and quantification, and Sandell’s sensitivity were calculated. The suggested procedures were further applied to the quantitative determination of tetracycline in pharmaceutical formulations.

How to cite this paper
Radhi, E., Ali, K & Hussein, F. (2023). Batch and merging-zone flow injection methods for determination of tetracycline hydrochloride.Current Chemistry Letters, 12(4), 677-684.

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Journal: Current Chemistry Letters | Year: 2023 | Volume: 12 | Issue: 4 | Views: 1093 | Reviews: 0

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