The study aimed to define the contribution of total quality management in relations with suppliers and customers in Jordanian pharmaceutical companies. The study population consisted of pharmaceutical companies in Jordan targeting individuals in supervisory positions in these companies. A total of 170 responses were received. The results of the study found that Jordanian pharmaceutical companies apply total quality management in terms of “commitment of senior management, employee empowerment, strategic planning for quality”, which had positive relationships with suppliers and customers. It indicates that total quality management and supply chain practices, especially the relationship with suppliers and customers, are among the basic concepts that work to improve supply chain performance. The study recommends devoting the necessary attention and care to empowering workers, and this is where the essential role-play for senior management is to create interest among employees in their work and jobs through training programs. However, developing methods of collective motivation, participating in setting goals, making decisions, and displaying the image of the work “Family” and forming problem-solving teams for the purpose of achieving empowerment is also important.