Safety is part of welfare which is the main goal of the organization seen from a humanistic management perspective. Safety is currently a very important factor for the existence of humans and organizations, so safety science becomes important to examine in depth human existence in activities to achieve prosperity. The method used is the Structure Equation Model (SEM). A total of 226 crew members working for the Indonesian National Shipping Company responded to this research questionnaire. The results show that the existential safety displayed by management who is committed to safety, active leaders facilitate safe work, and training that does not only touch the physical technical aspect but also touches the mental and spiritual aspects of humans to support safer performance. Also, the self-awareness of each crew member influences forming cohesiveness among them to behave in a collective safety manner. The theoretical contribution of this research is to study safety based on humanistic management theory. The managerial implication of this research is that safety is the responsibility of everyone who works in the organization, core management values are brought to life in collective safety behavior and leaders show that safety commitment in real attitudes and behavior. This research is still limited to focus on the philosophy of anthropology, metaphysics, and humanist management theory. Future research is expected to be able to get out of the influence of neo-liberal capitalist management theory and enter into a more humanist safety management based on metaphysical ontology philosophy and humanistic management theory and other social sciences.