Synthesis of the new metal complexes, by allowing the condensation of Ligand, HL, (E)-N'-(2-hydroxy-5-methoxybenzylidene)-4-methyl-1,2,3-thiadiazole-5-carbohydrazide (3) with some transition metals. Here an attempt is also made to compare reported conventional methods with microwave irradiation for synthesized compounds. Spectroscopic technique, IR, ¹H-NMR, C¹³NMR, elemental analysis and TGA-DTA were used to characterize synthesized ligands and their complexes. The metal complexes were also evaluated for in vitro antimicrobial screening.

A famous cisplatin anticancer agent is one of the most widely used chemotherapeutics for treating several human solid tumors. Toxicity of the normal cell is a life-threatening issue that restricts the therapeutic potential of cisplatin complex as an anticancer drug. Even though every year thousands of cisplatin-based analogs have been prepared, screened, and reported, only very few compounds entered the medical trials. Hence, new research work is still sensible. In the last few years, many mononuclear and polynuclear platinum complexes have been considerably investigated, in vitro and in vivo studies evaluated, with some compounds demonstrating significant anticancer potential. In this review, various mono-metallic and poly-metallic platinum‐based complexes with various derivatives used as ligands that have anticancer potential are defined and numerous typical examples are discussed briefly. Present investigation, numerous mononuclear cisplatin derivatives exhibited greater anticancer potency than the parent cisplatin drug. However, polynuclear cisplatin derivatives showed much better anticancer activity than mononuclear cisplatin analogs against various cancer cell lines.

Some new hydrazine complexes of trivalent lanthanide 3,3’-thiodipropanoates of empirical formulae [M(N₂H₅)(tdp)₂] and [Pr(N₂H₅)(tdp)₂·H₂O], where M = La, Ce, Sm and Nd, H₂tdp = 3,3’-thiodipropanoic acid, have been prepared and characterized by elemental analysis, mass, FTIR, Raman and electronic spectral, powder X-ray diffraction, scanning electron microscopy (SEM) and simultaneous TG–DTA techniques. The presence of bidentate carboxylate anion and coordinated N2H5 in these complexes are confirmed by IR spectra. TGA/DTA results confirmed that all the rare earth metal complexes give the corresponding metal carbonate (heating up to 1000 °C) through a metal oxalate intermediate. SEM images of Pr2O3 residue obtained from its complex show nano-sized clusters, thus the complex may be used as a precursor for nano-Pr₂O₃ preparation. The synthesized complexes show good antimicrobial activity against six bacteria (Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, and Serratia species) and four fungi (Candida albicans, Aspergillus niger, Aspergillus fumigatus, and Penicillium variance) as assessed by in vitro biological activity.

A new series of transition metal complexes of Co(III), Ni(II) and VO(IV) was synthesized with the bidentate Schiff base ligand (HL) derived from the condensation of 2-amino-3-benzyloxypyridine and 5-bromo salicylaldehyde. The synthesized Schiff base ligand and its metal complexes C1-C6 were structurally characterized by satisfactory elemental analysis, spectral studies such as (Mass, IR, ¹H and ¹³C NMR, conductance measurement, UV-vis and magnetic measurements) and thermal studies. The structure of HL was authenticated by X-ray single-crystal analysis. Hirshfeld surface analysis was carried out to understand the nature of intermolecular contacts, the fingerprint plot provides the information about the percentage contribution. Square-pyramidal geometry is proposed for VO(IV) complexes whereas octahedral geometry for Co(III) and Ni(II) complexes. The Schiff base ligand and its metal complexes have been tested in vitro for their antibacterial activities by using well diffusion method against Gram positive bacteria B. subtilis, S. aureus and Gram negative bacteria S. typhi, E. coli and antifungal activities against A. niger, A. flavus, C. albicans and A. Solani. The antimicrobial activity data show that metal complexes are more potent than the parent ligand.

In the present work, Zn(II), Co(II) and Cr(II) metal complexes (3-5) of N-hydroxy-4-[(hydroxyimino)methyl]benzamidine ligand (2) were synthesized and their anti-HIV activity by inhibiting reverse transcriptase was explored. Structural characterization using NMR, FTIR, Mass, UV-Vis spectra, TGA, magnetic moment and elemental analyses were performed. The analyses show that geometry, lipophilicity and steric factor play crucial role. Cell viability test is performed on peripheral blood mononuclear cells to check toxicity of prepared compounds on immune system, shows toxicity only at higher concentration. Antimicrobial activity and DNA cleavage analysis have also been studied and reported.

A series of novel metal complexes containing metal atoms such as Zn, Co, Cu, Cd, Ni, Mg and Sn have been synthesized from 3-(1,3-benzoxazol-2-yl)naphthalen-2-ol. The synthesized ligand was well characterized by IR, 1H-NMR and mass spectrometry. The electrochemical properties were studied by cyclic voltammetric analysis. The synthesized complexes are fluorescent and absorb in the range of 317 to 323 nm while emit in the range of 371 to 416 nm with good quantum yield. All metal complexes show significant in vitro antibacterial activity against E. coli and S. aureus strains and in vitro antifungal activity against C. albicans and A. niger strains by using serial dilution method. The antibacterial activities were expressed as the minimum inhibitory concentration (MIC) in ?g/mL.