A famous cisplatin anticancer agent is one of the most widely used chemotherapeutics for treating several human solid tumors. Toxicity of the normal cell is a life-threatening issue that restricts the therapeutic potential of cisplatin complex as an anticancer drug. Even though every year thousands of cisplatin-based analogs have been prepared, screened, and reported, only very few compounds entered the medical trials. Hence, new research work is still sensible. In the last few years, many mononuclear and polynuclear platinum complexes have been considerably investigated, in vitro and in vivo studies evaluated, with some compounds demonstrating significant anticancer potential. In this review, various mono-metallic and poly-metallic platinum‐based complexes with various derivatives used as ligands that have anticancer potential are defined and numerous typical examples are discussed briefly. Present investigation, numerous mononuclear cisplatin derivatives exhibited greater anticancer potency than the parent cisplatin drug. However, polynuclear cisplatin derivatives showed much better anticancer activity than mononuclear cisplatin analogs against various cancer cell lines.

Some new hydrazine complexes of trivalent lanthanide 3,3’-thiodipropanoates of empirical formulae [M(N₂H₅)(tdp)₂] and [Pr(N₂H₅)(tdp)₂·H₂O], where M = La, Ce, Sm and Nd, H₂tdp = 3,3’-thiodipropanoic acid, have been prepared and characterized by elemental analysis, mass, FTIR, Raman and electronic spectral, powder X-ray diffraction, scanning electron microscopy (SEM) and simultaneous TG–DTA techniques. The presence of bidentate carboxylate anion and coordinated N2H5 in these complexes are confirmed by IR spectra. TGA/DTA results confirmed that all the rare earth metal complexes give the corresponding metal carbonate (heating up to 1000 °C) through a metal oxalate intermediate. SEM images of Pr2O3 residue obtained from its complex show nano-sized clusters, thus the complex may be used as a precursor for nano-Pr₂O₃ preparation. The synthesized complexes show good antimicrobial activity against six bacteria (Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, and Serratia species) and four fungi (Candida albicans, Aspergillus niger, Aspergillus fumigatus, and Penicillium variance) as assessed by in vitro biological activity.