In increasing their productivity and attitudes in serving the community, every work they do should be considered meaningful both for themselves and for others. Many aspects influence the emergence of meaningful work, including the spiritual leadership style applied by the leader to his subordinates, the spirituality factor in the workplace that affects, and the internal need factors that are reflected in the form of self-transcendence. This is where the strategic function of the institution plays a role in coordinating and integrating spiritual leadership, spiritual workplace, self-transcendence within the individual and the creation of meaningful work is based on the principle of benefits both for themselves and for society so that the function of the Government as a public servant can run well. The purpose of this study was to examine and analyze the relationship between spiritual leadership and spirituality in the workplace towards self-transcendence and realizing meaning in work (Meaningful Work). The population of this study was ASN from 5 agencies and agencies under the Bengkulu city government, namely the Education Office, the Population and Civil Registration Service, the Health Service, the Tourism Office, the Youth and Sports Service. The number of samples was 150 people by convenience sampling method. The research method begins with validity and reliability testing with Confirmatory Factor Analysis. This is followed by an explanation of the statistical descriptions related to the respondent's profile, hypothesis testing using the SEM method by taking into account the goodness of fit test. The results showed that all hypotheses were accepted except the hypothesis of the effect of spiritual leadership on meaningful work by mediating self-transcendence.