A clean and efficient, mediated in water and assisted by ultrasound method for the synthesis of a series of N-substituted 1-amino-3-ferrocenyl-3-oxoprop-1-enes starting from acetyl ferrocene was developed. Our approach offers shortening of the reaction time under the mild reaction conditions and easy work up procedure.

(E)-3-(2-Methyl-1H-indol-3-yl)-1-(4-methylphenyl)propenone has been prepared, and its crystal structure (C19H17NO, Mr = 275.34) has been determined by single-crystal X-ray diffraction analysis. The title compound crystallized in the triclinic system with space group P1 and unit cell parameters: a = 9.4014 (5) ?, b = 9.8347 (4) ?, c = 10.0318 (5) ?, ? = 62.821 (3)°, B = 85.539 (3)°, ? = 65.262 (3)° and Z = 2. The final reliability index is 0.053 for the 2807 observed reflections. The title compound is linked through N–H···O hydrogen bonds.

The title compound 3-amino-5-(4-chlorophenyl)pyridazine-4-carbonitrile was prepared by a one-pot three-component reaction of malononitrile with corresponding arylglyoxal in the presence of hydrazine hydrate at room temperature in water and ethanol. Its structure was also con?rmed by its IR, 1H, 13C-NMR, Mass spectral data and elemental analysis. The compound was crystallized in the monoclinic system, space group P21/c, a = 3.817(3) ?, b = 13.533(10) ?, c = 19.607(15) ?, B = 93.401(10)°, Z=4, R1 = 0.0906 and wR2 = 0.1422. The crystal structure of the compound also shows a weak intermolecular interaction between N1 atom of one molecule and N3 atom of the other molecule.

The title compound 3-(4-hydroxy-3-methoxyphenyl)-7,7-dimethyl-7,8-dihydrocinnolin-5(6H)-one (3) was prepared via one-pot three component reaction of 2-(4-hydroxy-3-methoxyphenyl)-2-oxoacetaldehyde with dimedone in the presence of hydrazine hydrate and studied by the single crystal X-ray diffraction method. Its structure was also con?rmed by IR, 1H and 13C NMR spectroscopy. Compound 3 was crystallized in the monoclinic system, space group P21/c, a = 7.921(2) ?, b = 11.566(4) ?, c = 16.986(6) ?, B = 107.338(5)°, V = 1485.5(8) ?3, Z = 4, R1 = 0.0559 and wR2 = 0.1253. The crystal structure of 3 also shows a weak interaction between O3 and N2 atoms.