Synthesis of 1, 2-disubstituted benzimidazoles by reaction of N-substituted benzene-1,2-diamine with different aldehydes was developed. This greener procedure proceeds with the help of oxygen in water at 60oC. The advantages of proposed method are catalyst-free conditions in water, short reaction time and excellent yields.

The automobile industry is an obvious indication of a country's economic development. Because it requires high performance and quality parts, it is also an innovation and comprehension intensive sector. Because of its deep forward and backward links with many key segments of the economy, the automobile sector is also prominent in India. Because of the strong supply support provided by various auto ancillary manufacturing companies, this sector has a strong multiplier effect and has the potential to be a driver of economic growth. The auto ancillary market is focused on the production and sale of transitional equipment and automotive parts used in the manufacture of automobiles. It is an important part of India's automotive industry. Such industries allow vehicle manufacturers to concentrate on their core competencies. The auto ancillary manufacturing Industry, with its high growth prospects, is one of the emerging industries in Indian markets. The Altman Z rating is a beneficial expedient for identifying a company's economic resilience and the probability of insolvency. The Z rating method was once used in this to find out to check the economic fitness of Indian auto ancillary manufacturing companies. The economic facts of 10 auto ancillary manufacturing companies listed groups on the National Stock Exchange (NSE) have been used to study each unique and rising market Altman Z rating formulae. The findings point out that not all the enterprises listed on the NSE are financially healthy. According to the study, some of the Indian auto ancillary manufacturing companies are sound and dependable without few companies, and some of the auto ancillary manufacturing companies are not likely to face monetary misery or insolvency soon.

In this study, a green and practical approach towards Hantzsch dihydropyridine synthesis of acridine-1,8-diones is introduced. Via the mentioned protocol, the one-pot condensation reaction of structurally diverse aromatic aldehydes, dimedone and NH4OAc was promoted by microwave radiation at solvent and catalyst-free conditions. Consequently, acridinedione products were produced in 81‒97% yields within 3‒8 min. The current protocol represents the prominent advantages in terms of the using a simple synthetic procedure, short reaction times, mild reaction conditions, high yield of the products as well as omission of hazardous and cost-effective organic solvents/reagents.

This study aimed to develop a model for developing a shared economy with an economic development approach in the Iranian sports industry. The research method was a two-stage exploratory combination of instrument making. In the qualitative part, the purposeful sampling method and theoretical saturation technique were performed. The tools used were to identify semi-structured interviews (with focus groups) and study documents. To ensure the validity and reliability of the study, the Lincoln and Guba evaluation methods were used. In the quantitative part, the research method was a descriptive survey. The statistical population was the economic activists in sports and sports marketing students. According to Cochran’s sample size determination formula, 384 people were considered as the sample. to collect data from the questionnaire of the framework model of the shared economy model in sports with an economic development approach that includes 43 items that have been extracted according to the theoretical foundations and the qualitative part of the research. Eight professors of sports management were used to evaluate the face validity and the carcass model was used for the content validity of the questionnaire questions. (CVR=0.86) and content validity was confirmed. Cronbach's approved alpha was also used. Descriptive statistics and structural equation modeling were used to analyze the data to evaluate the fit of the research model. The results of the research in the qualitative section showed that after examining the Delphi method and performing the first stage, 31 items were identified. In the second stage, 40 items were identified, and in the third stage; Finally, 50 items were identified. The three dimensions of human ecology, fiscal policy, and value-oriented processes emerged as a framework for the model of a shared economy in sports with an economic development approach. And in the quantitative part, the human ecology dimension with a value of 0.71 affects the value-oriented process dimension with a value of 0.65 and the fiscal policy dimension with a value of 0.63 affects the framework for the development of a shared economy in sport. The results also showed that the research model has a good fit. Therefore, it is suggested that the sports organizations' managers pay attention to the factors of this research to implement economic development by emphasizing a shared economy.

Seafood processing operations generate a high strength wastewater, which contain organic pollutants in soluble, colloidal, particulate form and salt content, up to 30g NaCl/L. This research aimed to study the effect of salt (NaCl) concentration on the treatment efficiency of seafood processing wastewater by the use of a laboratory-scale bioreactor, which is operated in anaerobic combining aerobic system with concentration salt different from 0- 5%. The results showed that the wastewater from seafood processing with the chemical input parameters of pH = 7 - 8.5, COD = 2000 mg / L, total nitrate nitrogen = 150 mg / L, NH⁴⁺ = 90 mg / L, total phosphorus = 50 mg / L, salt content 3% was treated with anaerobic activated sludge content of 8000mg/l, 16HRT and combining an aerobic activated sludge content of 6000mg/l, 6HRT, DO=2-4mgO₂/l with the acclimatization of 7% bacteria Bacillus velezensis at high salinity The parameters output wastewater was treated according to standards QCVN 11-MT:2015/BTNMT (column B).

This study proposes Q-learning-based iterated greedy (IGQ) algorithms to solve the blocking flowshop scheduling problem with the makespan criterion. Q learning is a model-free machine intelligence technique, which is adapted into the traditional iterated greedy (IG) algorithm to determine its parameters, mainly, the destruction size and temperature scale factor, adaptively during the search process. Besides IGQ algorithms, two different mathematical modeling techniques. One of these techniques is the constraint programming (CP) model, which is known to work well with scheduling problems. The other technique is the mixed integer linear programming (MILP) model, which provides the mathematical definition of the problem. The introduction of these mathematical models supports the validation of IGQ algorithms and provides a comparison between different exact solution methodologies. To measure and compare the performance of IGQ algorithms and mathematical models, extensive computational experiments have been performed on both small and large VRF benchmarks available in the literature. Computational results and statistical analyses indicate that IGQ algorithms generate substantially better results when compared to non-learning IG algorithms.

This study aims to examine customer retention (CR) from the aspect of customer satisfaction with customer relationship management (CRM), service quality and marketing relations (RM). State-owned bank customers selected the research population in all branch offices in the Madura region, and data were collected through a Likert scale model questionnaire. The results of the path analysis using the structural analysis model (SEM) show that there is an influence of CRM on customer satisfaction; there is an effect of service quality on customer satisfaction; there is an effect of RM on customer satisfaction; CRM through customer satisfaction affects CR; service quality through customer satisfaction affects CR; RM through customer satisfaction affects CR; there is an effect of customer satisfaction on CR on customers. Then the simultaneous test shows that simultaneously RM, service quality, and RM impact customer satisfaction, and the value of coefficient of determination (R-Square) explains that CRM, service quality, and RM can effectively contribute to customer satisfaction. Simultaneously, CRM, service quality, and RM affect CR. CRM, service quality, and RM affect CR mediated by customer satisfaction. CRM, service quality, and RM, through customer satisfaction, can effectively contribute to CR to customers of state-owned bank Regional Offices.

Five imidazo[1,2-c]pyrimidine and pyrimido[1,6-a]pyrimidine derivatives were designed, synthesized and evaluated for their antiproliferative activity and cytotoxicity. Primary bioassays in vitro showed that two of five synthesized compounds, 6-benzyl-8-(methylsulfonyl)-2,6-dihydroimidazo[1,2-c]pyrimidin-5(3H)-one, and 9-(methylsulfonyl)-7-propyl-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-one possessed potent antiviral activity against BKV (EC50: 0.66 μM and 0.96, respectively). The selectivity index of these compounds is similar to that of cidofovir. Although antiviral activity was evident in secondary assays, significant virus inhibition occurred at or near the cytotoxic concentration (SI90=1). Here we show that substituted pyrimidine derivatives are a promising structure class of chemical compounds for the development of antiviral drugs against BKV infections. Hence these compounds may be taken as lead compounds for further development of novel antimicrobial and anticancer agents.

Portfolio optimization aims to minimize risk and maximize return on investment by determining the best combination of securities and proportions. The variance in portfolio optimization models is typically used for a measure of risk. Over the last few decades, portfolio optimization utilizing a variety of risk measures has grown significantly, and many studies have been conducted. Therefore, this paper provides a systematic review of risk measures for portfolio optimization using bibliometric analysis and maps to analyze the evolution and trends of 682 articles published between 2000 and 2022. Throughout this analysis, communication networks among articles, authors, sources, countries, and keywords are explored. Furthermore, a classification of risks and risk measures were presented to demonstrate a comprehensive overview of the field, and the top 50 papers were analyzed to determine which risk measures were most often used in recent studies.

[Leu]⁶-aureobasidin K 1 is an analog of AbK, in which aIle residue at the sixth position of AbK is replaced by Leu. [Leu]⁶-AbK 1 was successfully synthesized using a combination of solid- and solution-phase that has a difference with the previous method applied for the synthesis of other aureobasidin analogues, [2S,3S-Hmp]-AbL 2. The linear precursor was prepared by using solid-phase method with Fmoc strategy, in which an ester bond was constructed on the resin. The cyclic product was obtained from a solution-phase reaction of the linear precursor using HATU reagent. The crude of the cyclic peptide was purified using a column chromatography technique to obtain [Leu]⁶-AbK 1 with a percent yield of 5.31% that is higher compared to previous similar method for synthesis of [2S,3S-Hmp]-AbL 2. The purity level of cyclic product was analyzed using analytical RP-HPLC (t_R = 6.49 min) and analysis of structure using ¹H-NMR.