The research aims to investigate how strategic entrepreneurship through innovative effectiveness is used to create value within firms. Using structural equation modeling, data from 55 private hospitals in Jordan were gathered. For this research, 230 directors, managers, and department heads were enlisted. An entrepreneurial mindset was found to have a significant and positive correlation with innovative effectiveness while having a business alignment also had a positive and significant correlation with innovative effectiveness. However, innovative effectiveness had a positive but insignificant correlation with the creation of firm value. The research concluded that strategic entrepreneurship had a positive effect on the creation of firm value.