This study aims to investigate the effects of job-related stressors and individual-related stressors on employee motivation, job satisfaction and employee loyalty in the context of Vietnam hospitality industry. Data were collected by surveying 595 employees including Hotel/Restaurant receptionist, low-level manager (shift/group leader, supervisor, etc.) and Middle level and high ranked manager (Chief/deputy chief of department, general manager, director, etc.) from medium to large Hotels and Restaurants in Ho Chi Minh City. Besides, the collected data was analyzed by employing partial least squares (PLS) technique. The results show that individual-related stressors positively and directly affect employee motivation, job satisfaction and employee loyalty while job-related stressors have a positive direct effect on employee motivation but indirectly affect job satisfaction and employee loyalty. This study provides critical contributions to the research field of the Hospitality industry as well as suggests some important recommendations for improving employee motivation, job satisfaction and employee loyalty in the context of Vietnam Hospitality.