This research aims to analyze the relationship between information system quality and user satisfaction, the relationship between perceived usefulness and user satisfaction and the relationship between user satisfaction and sustainable e-learning. The research method used in this research is associative research. The population in this study were all students who had undergone lectures using e-learning. In this study, the analytical model was used, namely Structural Equation Modeling (SEM) and the number of respondents was 456 high school students in Indonesia, who have undergone lectures using e-learning. The sampling technique used in this research is nonprobability sampling. The data collection method used was the questionnaire method and the instrument used to measure this research variable was a 5-point Likert scale. Data processing in this research uses SmartPLS software. The data analysis stage in this research is the outer model test including convergent validity, discriminant validity and composite reliability and inner model analysis, namely hypothesis testing. The results of the study indicate the quality of the information system has a positive effect on user satisfaction, Perceived Usefulness has a positive effect on user satisfaction and user satisfaction has a positive effect on sustainable e-learning. The implication is that every element at every level in formal educational institutions must pay serious attention to personal factors, including attention to student achievement expectations, relative excellence expected by students, student suitability with the e-learning system chosen in an institution's formal education, and the attitude of students who are willing to accept and continuously use e-learning. In this way, students will be consistent in using e-learning so that student achievement, which is the main goal of every school, can be achieved. The limitation of this research is that it does not provide prior understanding to respondents regarding the scope of the meaning of sustainable e-learning.