This research aims to empirically assess the impact of supply chain 4.0 and supply chain risk on organizational performance in the food manufacturing industry in the United Arab Emirates (UAE). Based on empirical evidence, only a few empirical research in supply chain 4.0 have been conducted. Additionally, they stress the significance of supply chain risk management assistance in enhancing organizational effectiveness. A quantitative technique with convenient cluster sampling was used to evaluate the variables. Data from 54 food manufacturing companies based in Ajman, UAE, was used. A sample size of 289 respondents was used for statistical analysis. The research findings revealed a strong link between the significant impact of supply chain4.0 and supply chain risk to improve organizational performance. The use of supply chain 4.0 in manufacturing organizations was the main focus of this study. The model can be modified to reflect other businesses worldwide, for instance, the retail or service sectors. The findings aid businesses in making better-informed decisions about adopting supply chain 4.0. According to the research findings, food manufacturing companies should initiate and advance their transition to supply chain 4.0 for them to be competitive, effective, and productive.