The study aimed to examine the relationship between knowledge-based systems, E-Systems, and Supply chain management (SCM) in competitive advantage. In order to achieve the objectives of the study, the researchers developed a questionnaire to collect the required data, where (120) questionnaires were left valid for analysis. SPSS Version 16 was used to analyze the study data. The most important results of this study were as follows: The perceptions of the respondents for knowledge-based systems (E-Systems) were at a high level. Also, the perceptions of the respondents for SCM were with a high degree. Furthermore, the perceptions of the respondents for competitive advantage were with a high degree. There is an effect for knowledge-based systems (E-Systems) and SCM in competitive advantage, and the dimensions of the dependent variable explained about 53% of variance in the variable of competitive advantage.