Benzotriazole, commonly referred to as BTAH, has garnered significant interest across several scientific disciplines due to its outstanding characteristics and wide-ranging applications. This document provides a concise overview of benzotriazole and its use in challenging corrosion scenarios. Furthermore, we emphasize the versatility of this molecule and the extensive research commitment associated with it. This thorough analysis examines the synthesis of benzotriazoles and their derivatives in-depth and encapsulates the numerous methods involved. Additionally, we conducted a thorough analysis of toxicity studies and the pertinent implications of benzotriazoles on human health, marine life, and the ecosystem. Our purpose is to provide readers with a thorough understanding of the potential dangers of this chemical by undertaking an extensive examination of associated risks and bad effects. During this review, we emphasize significant research discoveries and trends, offering useful insights into the current status of benzotriazole research and its future potential. The development of such research advances from 2010 to 2024.

Fused heterocyclic derivatives have become an important scaffold nowadays, which could be used as a template in drug development and medicinal chemistry. Benzimidazole moiety is an imperious aromatic heterocycle which is frequently present in naturally occurring products such as purines, vitamin B 12 and histidine as well as synthesized bioactive compounds, indomethacin and albendazole, for example. This study comprises widespread and comprehensive literature analysis on chemical reactivity and biological properties associated with Benzimidazole containing molecules. Benzimidazole ring structure possesses an extensive variety of pharmacological activities in several medications of therapeutic interest against a variety of diseases such as hypertension, malaria, cancer, microbial diseases, inflammatory disorders, etc. Furthermore, this fused heterocycle benzimidazole core might interact with various anions and cations in addition to biomolecules over different reactions in the human body, therefore exhibiting wide-ranging biological activities such as antineoplastic, antibacterial and antifungal, anti-inflammatory and analgesic, antihypertensive, antiviral and antidepressant. In this review, we are focusing on the chemistry and recent biological activities, designing approaches, and SAR (structure-activity relationship) data of different benzimidazole-based analogues during the past years.