Employees’ knowledge sharing and innovative work behavior play an important role for the development of Vietnam telecommunication enterprises. Knowledge sharing along with two central processes; namely knowledge donation and collection, fosters employees’ innovative work behavior of Vietnam telecommunication enterprises. Based on a sample size survey of 396 Vietnam telecommunication employees and exploration factor analysis (EFA), confirmatory factor analysis (CFA) and structural equation modeling (SEM), the study determines factors such as trust, enjoyment in helping others, knowledge self-efficacy, management support, using information and communication technology significantly influence knowledge donation and collection. At the same time, knowledge donation and collection have positive impacts on employees’ innovative work behavior of Vietnam telecommunication enterprises. Finally, several suggestions for enhancing employees’ knowledge sharing and innovative work behavior of Vietnam telecommunication enterprises managers are given.