The aim of this research is to investigate the gap or SERVQUAL scale amongst the findings of the previous studies for missing investigations and the impression to apply for overall standard quality management of three variables such as independent variable (Service quality), mediator variable (Patients’ Satisfaction) and dependent variable (Patients’ Loyalty) in Jordanian health care sector. Moreover, the current study aims to clarify the effects of the Total Quality Management (TQM) represented collectively by a specific strategy, leadership management, human resource focus information, client focus, method management, and analysis method management on customer loyalty. In order to test the objectives, a random sample size consisting of 800 national and international patient’s expectations from the private and public hospitals in the central region of Jordan was collected. The quantitative analysis was designed to conduct the survey, questionnaires, and gather the primary information to determine the category of data and techniques of data collection. The response data were analyzed using the IBM SPSS 19.00 version and Amos 20.00 version to assess the response value, descriptive statistic, screenings of the data composed of linearity and homoscedasticity, correlations, reliability, and validity. Multiple reliability results indicated that the dimensions of each experimental variables were considered reliable and satisfactory. Based on the outcome, this study verified that customer satisfaction carries a weak mediating effect. Moreover, the results exhibited that TQM had had a significant impact on both customer loyalty and customer satisfaction.