The main purpose of this research is to investigate the mediating role of job stress in the relationship between organizational change and job satisfaction in telecommunication companies in Jordan. The research population is employees working at three communication companies in Jordan; as a convenience sample of 422 was chosen randomly. Descriptive analysis was used to provide general information on the employees of telecommunication companies. Furthermore, validity and reliability tests were used, and regression analysis was applied for the possibility of hypotheses rejection. The findings indicate a significant positive relationship between organizational change and job satisfaction, as well as a significant positive relationship between organizational change and job stress. Additionally, the results indicate a significant negative relationship between job stress and job satisfaction. The findings also revealed a partial mediating effect of job stress on the relationship between organizational change and job satisfaction. According to the findings of this research, to increase employees’ job satisfaction, their level of job stress during organization change operations in telecommunication companies must be decreased. For future research, the present study recommends the investigation of the impact of organizational change on job satisfaction, along with the mediating role of job stress, using different dimensions and sectors.