The main problem in this research, among others, was the lack of attention given by the company management to the seafarers' demands concerning health, social aspects, work stress, work environment, work facilities, and working hours that increased seafarers' pressure. The aim of this research was to analyze the influence of job satisfaction and work stress on shipping safety with seafarer performance as the intervening variable. The research was carried out in Balai Pendidikan dan Pelatihan Ilmu Pelayaran (Center for Maritime Education and Training) Tangerang with the samples of 93 seafarers working in several shipping companies. Data was processed using Path analysis. The result of this research showed that job satisfaction and work stress directly influenced seafarer performance. Meanwhile, job satisfaction and work stress had an indirect influence on shipping safety through seafarer performance, and seafarer performance had a direct influence on shipping safety. The result of Path analysis showed that work stress rather than job satisfaction had a bigger influence on seafarer performance, and seafarer performance had the biggest direct influence on shipping safety.