In the current competitive environment, managers do their best to convert organizations under their supervision into competitive and responsive through creating capability of timely delivery of quality products and services. In the other word, they try to create value for their customers, which yield more profitability for stakeholders. In line with this, determining of inter-organizational factors and the relationships among these variables and supply chain performance plays an important role in achieving these objectives. The relationship modeling is a type of multiple criteria decision-making (MCDM) problem, which requires applying experts to determine the relationships. The Decision Making Trial and Evaluation Laboratory (DEMATEL) is an MCDM tool, which not only can convert the relationships among cause and effect criteria into a visual structural framework, but also it can be used as a technique to handle the inner dependences within a set of criteria. This paper proposes an effective solution based on DEMATEL approach to help managers evaluate the relationships between inter-organizational factors and supply chain performance.