This paper investigates the effects of different factors influencing on the successful implementation of the business process re-engineering (BPR) in Iran. The study selects 386 experts randomly and using some statistical tests examines the effects of four groups of factors including strategic, organizational, methodologic and technological & educational issues on the success of the BPR implementation in Iran. The study designs a questionnaire in Likert scale and distributes it among some experts where Cronbach alpha was calculated as 0.71. The implementation of Pearson correlation ratio has confirmed that technological and educational factors marinated the highest effects (r = 0.523, Sig. = 0.000) followed by strategic (r = 0.505, Sig. = 0.000), organizational (r = 0.352, Sig. = 0.000) and methodologic issues (r = 0.267, Sig. = 0.000). In addition, the implementation of Stepwise regression has confirmed that technological & educational, strategic and methodologic factors influence on BPR in Iran.