This study focuses on the impact of the digital supply chain, including digital suppliers, digital manufacturing, and digital logistics, on sustainability outcomes in pharmaceutical companies in Jordan. Quantitative data were collected through a questionnaire distributed to a sample of 226 managers of pharmaceutical companies in Jordan. The questionnaire measures perceptions, attitudes and experiences related to digital supply chain adoption and sustainability performance. Structural equation modeling (SEM) was used as an analytical framework to study the relationships between digital supply chain and sustainability outcomes. The hypothesized relationships were tested using confirmatory factor analysis and path analysis techniques within the SEM framework. The results indicate a positive relationship between digital supply chain adoption and sustainability performance in pharmaceutical companies in Jordan. Based on the results, several recommendations were proposed for pharmaceutical companies in Jordan to enhance their sustainable performance through digital supply chain initiatives. This research contributes to the existing literature by providing empirical evidence on the relationship between digital supply chain practices and sustainability outcomes in the pharmaceutical industry, especially in the context of Jordan.