Creating and maintaining a healthy organization is a major challenge of organizational leaders in the current volatile and competitive business environment. One of the critical aspects of a healthy organization is employees’ mental wellbeing. Aspects like workplace spirituality and mindfulness are now highly popular among organizations. However, studies linking these variables with employees’ wellbeing is an area that has not received adequate research attention. The pivotal objective of this study is to explore the combined effect of mindfulness and workplace spirituality on employees’ mental wellbeing. A cross-sectional research design was adopted for the study, and data were collected from 333 full-time employees working in diverse industries. Results reveal significant relationship between the three variables. It was also found that both workplace spirituality and mindfulness were significant predictors of mental wellbeing. The present study, enriches the literature by contributing towards an understanding of the causative factors of employees’ mental wellbeing and how it can be improved in the organizations.