The purpose of this study was to investigate and examine the moderating effect of Strategic Thinking on the effect of Talent Management on Core competence. The study collected the primary data from the sample that comprise of 310 managers working in Saudi private hospitals lied in western region, using well-designed questionnaire. The study planned to learn how Talent Management, Core Competence, and Strategic Thinking can affect each other in private hospitals, which can re-veal the latent potentials of human resources that enable the hospitals to achieve competitive positions. SEM model was developed and carefully assessed. The key findings indicate that enhancing managers’ strategic thinking could result in increasing the opportunity for hospitals to achieve core competences through applying talent management practices. As a result, the relationship between Talent Management and Core competence, as well as the relationship between Strategic Thinking and Core competence, was positive. Given these relationships, it can be concluded that the strategic thinking (as a moderating variable) can have a positive effect on the relationship between talent management and core competence.