Government construction projects are vital to the economic development of developing countries. However, although most of these projects suffer from abandonment, little evidence exists concerning the causes that account for this setback. This paper investigates the causes of government construction project abandonment in Ghana. We used a sequential data collection approach, in-depth semi-structured interviews, and questionnaire surveys to solicit the views of project management practitioners, contractors, and clients associated with Ghana government construction project implementation. Using factor analysis and structural equation modelling, we find that Ghanaian government construction project abandonment is influenced by five sets of causes: political leadership, culture, external forces, resources (including funding) and administrative/institutional bottlenecks. Three of these sets of causes – political leadership, cultural and external forces, are the primary causes, while resources (including funding) and administrative/institutional causes are secondary causes.