On average, Guangxi experiences 2 severe tropical cyclone disasters yearly. A large number of disaster victims need governments at all levels to raise enough emergency supplies to carry out effective relief. However, there is no proper reserve center for tropical cyclone disaster storage and collection of emergency supplies in Guangxi, so it is urgent to choose a suitable location to build the Guangxi tropical cyclone disaster emergency supplies reserve center. The data of 16 severe tropical cyclone disasters and rescues in Guangxi from 2014 to 2021 were collected. An optimal location model of the emergency supplies reserve center for tropical cyclone disasters in Guangxi was established using the improved center of gravity method based on GIS. After four iterations of calculation, the longitude and latitude coordinate S5(108.64, 21.98) were used as a suitable site to construct the Guangxi Tropical Cyclone Disaster Emergency Supplies Reserve Center to ensure the fastest and lowest cost delivery of emergency supplies to the disaster areas in Guangxi. According to the map of Tiandi, the actual place corresponding to this coordinate is near Liuwu Village next to Qinzhou East Railway Station, Qinnan District, Qinzhou, Guangxi. This location coordinate S5 can provide a reference for the Guangxi Zhuang Autonomous Region government to select a suitable address to construct the Guangxi Tropical Cyclone Disaster Emergency Supplies Reserve Center. The improved center of gravity location model based on GIS can also provide a reference for other provinces or cities to carry out emergency supplies reserve center locations.